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Rabbit Anti-SSTR1 Recombinant Antibody (CBXS-5571) (CBMAB-S2778-CQ)


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Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBXS-5571
Antibody Isotype
IgG
Application
WB, IF

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
somatostatin receptor 1
Introduction
Somatostatins are peptide hormones that regulate diverse cellular functions such as neurotransmission, cell proliferation, and endocrine signaling as well as inhibiting the release of many hormones and other secretory proteins. Somatostatin has two active forms of 14 and 28 amino acids. The biological effects of somatostatins are mediated by a family of G-protein coupled somatostatin receptors that are expressed in a tissue-specific manner. The protein encoded by this gene is a member of the superfamily of somatostatin receptors having seven transmembrane segments. Somatostatin receptors form homodimers and heterodimers with other members of the superfamily as well as with other G-protein coupled receptors and receptor tyrosine kinases. This somatostatin receptor has greater affinity for somatostatin-14 than -28.
Entrez Gene ID
6751
UniProt ID
P30872
Alternative Names
Somatostatin Receptor 1; SRIF-2; SS-1-R; SS1-R; SS1R; Somatostatin Receptor Type 1;
Function
Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and Na+/H+ exchanger via pertussis toxin insensitive G proteins.
Biological Process
Biological Process cellular response to estradiol stimulusManual Assertion Based On ExperimentIBA:GO_Central
Biological Process cellular response to leukemia inhibitory factorIEA:Ensembl
Biological Process cerebellum developmentIEA:Ensembl
Biological Process forebrain developmentIEA:Ensembl
Biological Process G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerManual Assertion Based On ExperimentTAS:ProtInc
Biological Process glutamate receptor signaling pathwayIEA:Ensembl
Biological Process negative regulation of cell population proliferationManual Assertion Based On ExperimentTAS:ProtInc
Biological Process neuropeptide signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Biological Process response to starvationIEA:Ensembl
Biological Process spermatogenesisIEA:Ensembl
Cellular Location
Cell membrane
Topology
Extracellular: 1-56
Helical: 57-84
Cytoplasmic: 85-94
Helical: 95-120
Extracellular: 121-131
Helical: 132-153
Cytoplasmic: 154-175
Helical: 176-196
Extracellular: 197-219
Helical: 220-244
Cytoplasmic: 245-270
Helical: 271-296
Extracellular: 297-303
Helical: 304-327
Cytoplasmic: 328-391
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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