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Mouse Anti-SSTR1 Recombinant Antibody (4E3) (CBMAB-A8616-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
4E3
Antibody Isotype
IgG2a, κ
Application
sELISA, ELISA

Basic Information

Immunogen
SSTR1 (AAH35618, 1 a.a. ~ 60 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
somatostatin receptor 1
Introduction
Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biological effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. The encoded protein is a member of the superfamily of somatostatin receptors having seven transmembrane segments, and is expressed in highest levels in jejunum and stomach. [provided by RefSeq]
Entrez Gene ID
6751
UniProt ID
P30872
Alternative Names
SRIF-2
Function
Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and Na+/H+ exchanger via pertussis toxin insensitive G proteins.
Biological Process
Biological Process cellular response to estradiol stimulusManual Assertion Based On ExperimentIBA:GO_Central
Biological Process cellular response to leukemia inhibitory factorIEA:Ensembl
Biological Process cerebellum developmentIEA:Ensembl
Biological Process forebrain developmentIEA:Ensembl
Biological Process G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerManual Assertion Based On ExperimentTAS:ProtInc
Biological Process glutamate receptor signaling pathwayIEA:Ensembl
Biological Process negative regulation of cell population proliferationManual Assertion Based On ExperimentTAS:ProtInc
Biological Process neuropeptide signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Biological Process response to starvationIEA:Ensembl
Biological Process spermatogenesisIEA:Ensembl
Cellular Location
Cell membrane
Topology
Extracellular: 1-56
Helical: 57-84
Cytoplasmic: 85-94
Helical: 95-120
Extracellular: 121-131
Helical: 132-153
Cytoplasmic: 154-175
Helical: 176-196
Extracellular: 197-219
Helical: 220-244
Cytoplasmic: 245-270
Helical: 271-296
Extracellular: 297-303
Helical: 304-327
Cytoplasmic: 328-391
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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