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Rat Anti-SDC2 Recombinant Antibody (CBXS-3418) (CBMAB-S6152-CQ)


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Summary

Host Animal
Rat
Specificity
Human
Clone
CBXS-3418
Antibody Isotype
IgG2b
Application
FC

Basic Information

Immunogen
Recombinant protein corresponding to aa19-144 of human Syndecan 2 expressed in NSO cells (AAH49836.1)
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
syndecan 2
Introduction
The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-2 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-2 expression has been detected in several different tumor types.
Entrez Gene ID
6383
UniProt ID
P34741
Alternative Names
Syndecan 2; Heparan Sulfate Proteoglycan 1, Cell Surface-Associated; Heparan Sulfate Proteoglycan Core Protein; Syndecan Proteoglycan 2; Fibroglycan; HSPG1; SYND2;
Function
Cell surface proteoglycan that bears heparan sulfate. Regulates dendritic arbor morphogenesis (By similarity).
Biological Process
Biological Process cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process dendrite morphogenesisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of dendrite morphogenesisISS:UniProtKB
Cellular Location
Membrane
Topology
Extracellular: 19-144
Helical: 145-169
Cytoplasmic: 170-201
PTM
O-glycosylated with core 1 or possibly core 8 glycans. Contains heparan sulfate.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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