Mouse Anti-MYH1 Recombinant Antibody (A4.1025) (CBMAB-0333-CN)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human, Amphibia, Rodent, Zebrafish

Clone

A4.1025

Antibody Isotype

IgG2a

Application

IF, IHC, WB

Basic Information

Immunogen

Myosin heavy chain (human MHC or MyHC) purified.

Specificity

Human, Amphibia, Rodent, Zebrafish

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

>95%, as determined by SDS-PAGE analysis

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

myosin heavy chain 1

Introduction

Myosin is a major contractile protein which converts chemical energy into mechanical energy through the hydrolysis of ATP. This gene is a hexameric protein composed of a pair of myosin heavy chains (MYH) and two pairs of nonidentical light chains. Myosin heavy chains are encoded by a multigene family. In mammals at least 10 different myosin heavy chain (MYH) isoforms have been described from striated, smooth, and nonmuscle cells. These isoforms show expression that is spatially and temporally regulated during development.

Entrez Gene ID

Human	4619
Zebrafish	768300

UniProt ID

Human

P12882

Alternative Names

MYHa; HEL71; MYHSA1; MyHC-2x; MyHC-2X/D

Function

Muscle contraction.

Biological Process

Muscle contraction Source: Ensembl

Cellular Location

Other locations
myofibril
Note: Thick filaments of the myofibrils.

More Infomation

References

Hau, H. T. A., Kelu, J. J., Ochala, J., & Hughes, S. M. (2023). Slow myosin heavy chain 1 is required for slow myofibril and muscle fibre growth but not for myofibril initiation. Developmental Biology, 499, 47-58.

Long, K., Su, D., Li, X., Li, H., Zeng, S., Zhang, Y., ... & Li, M. (2022). Identification of enhancers responsible for the coordinated expression of myosin heavy chain isoforms in skeletal muscle. BMC genomics, 23(1), 1-13.

Valberg, S. J., Schultz, A. E., Finno, C. J., Bellone, R. R., & Hughes, S. S. (2022). Prevalence of clinical signs and factors impacting expression of myosin heavy chain myopathy in Quarter Horse‐related breeds with the MYH1 E321G mutation. Journal of Veterinary Internal Medicine, 36(3), 1152-1159.

Ochala, J., Finno, C. J., & Valberg, S. J. (2021). Myofibre hyper-contractility in horses expressing the myosin heavy chain myopathy mutation, MYH1E321G. Cells, 10(12), 3428.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
Request for COA

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Second antibody and isotype control

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