Mouse Anti-MYHB Antibody (NA4) (CBMAB-0884-YC)

See all MYH1 antibodies

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Datasheet

Summary

Host Animal

Mouse

Specificity

Chicken

Clone

NA4

Antibody Isotype

IgG1

Application

Basic Information

Specificity

Chicken

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Supernatant

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

myosin heavy chain 1

Introduction

Myosin is a hexameric protein composed of a pair of myosin heavy chains (MYH) and two pairs of nonidentical light chains. In mammals at least 10 different myosin heavy chain (MYH) isoforms have been described from striated, smooth, and nonmuscle cells. MYH1 (myosin heavy chain, sarcomere) is a heavy chain of myosin.

Alternative Names

MYH1; myosin heavy chain

Function

Muscle contraction.

Biological Process

Muscle contraction Source: Ensembl

Cellular Location

Other locations
myofibril
Note: Thick filaments of the myofibrils.

More Infomation

References

Hau, H. T. A., Kelu, J. J., Ochala, J., & Hughes, S. M. (2023). Slow myosin heavy chain 1 is required for slow myofibril and muscle fibre growth but not for myofibril initiation. Developmental Biology, 499, 47-58.

Long, K., Su, D., Li, X., Li, H., Zeng, S., Zhang, Y., ... & Li, M. (2022). Identification of enhancers responsible for the coordinated expression of myosin heavy chain isoforms in skeletal muscle. BMC genomics, 23(1), 1-13.

Valberg, S. J., Schultz, A. E., Finno, C. J., Bellone, R. R., & Hughes, S. S. (2022). Prevalence of clinical signs and factors impacting expression of myosin heavy chain myopathy in Quarter Horse‐related breeds with the MYH1 E321G mutation. Journal of Veterinary Internal Medicine, 36(3), 1152-1159.

Ochala, J., Finno, C. J., & Valberg, S. J. (2021). Myofibre hyper-contractility in horses expressing the myosin heavy chain myopathy mutation, MYH1E321G. Cells, 10(12), 3428.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Datasheet
SDS
Request for COA

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Second antibody and isotype control

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