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Rabbit Anti-CTBP2 Recombinant Antibody (CBWJC-2075) (CBMAB-C2757WJ)


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Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
CBWJC-2075
Antibody Isotype
IgG
Application
WB, IHC-P, ICC

Basic Information

Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
C-Terminal Binding Protein 2
Introduction
CTBP2 (C-Terminal Binding Protein 2) is a Protein Coding gene. Diseases associated with CTBP2 include Retinitis Pigmentosa 14 and Deafness, Autosomal Recessive 9. Among its related pathways are Chronic myeloid leukemia and Mesodermal Commitment Pathway. Gene Ontology (GO) annotations related to this gene include chromatin binding and transcription corepressor activity. An important paralog of this gene is CTBP1.
Entrez Gene ID
Human1488
Mouse13017
Rat81717
UniProt ID
HumanP56545
MouseP56546
RatQ9EQH5
Alternative Names
C-Terminal Binding Protein 2; C-Terminal-Binding Protein 2; Ribeye; CtBP2;
Function
Corepressor targeting diverse transcription regulators. Functions in brown adipose tissue (BAT) differentiation (By similarity).

Isoform 2 probably acts as a scaffold for specialized synapses.
Biological Process
Cellular response to leukemia inhibitory factor Source: Ensembl
Negative regulation of cell population proliferation Source: ProtInc
Negative regulation of transcription, DNA-templated Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: ARUK-UCL
Positive regulation of chromatin binding Source: Ensembl
Positive regulation of retinoic acid receptor signaling pathway Source: MGI
Positive regulation of transcription by RNA polymerase II Source: MGI
Synaptic vesicle docking Source: Ensembl
Viral genome replication Source: ProtInc
White fat cell differentiation Source: UniProtKB
Cellular Location
Nucleus; Synapse
More Infomation

Wang, Q., & Wu, Q. (2022). Knockdown of receptor interacting protein 140 (RIP140) alleviated lipopolysaccharide-induced inflammation, apoptosis and permeability in pulmonary microvascular endothelial cells by regulating C-terminal binding protein 2 (CTBP2). Bioengineered, 13(2), 3981-3992.

Aoyagi, T., Yoshino, R., Mitsuta, Y., Morita, R., Harada, R., & Shigeta, Y. (2022). Integrated In Silico Studies on the Role of Nicotinamide Adenine Dinucleotide (NADH) Binding in Activating C-Terminal Binding Protein 2 (CtBP2). Chemistry Letters, 51(1), 1-4.

Li, B., Xiang, Z., Xiong, F., Yan, B., & Huang, Q. (2020). C-terminal binding protein-2 is a prognostic marker for lung adenocarcinomas. Medicine, 99(31).

Wang, P., Yu, B., Wang, C., & Zhou, S. (2020). C-terminal of E1A binding protein 2 promotes the malignancy of osteosarcoma cells via JAK1/Stat3 signaling. Journal of cell communication and signaling, 14(1), 67-76.

Wang, D. P., Gu, L. L., Xue, Q., Chen, H., & Mao, G. X. (2018). CtBP2 promotes proliferation and reduces drug sensitivity in non-small cell lung cancer via the Wnt/β-catenin pathway. Neoplasma, 65(6), 888-897.

Shi, H., Mao, Y., Ju, Q., Wu, Y., Bai, W., Wang, P., ... & Jiang, M. (2018). C-terminal binding protein‑2 mediates cisplatin chemoresistance in esophageal cancer cells via the inhibition of apoptosis. International journal of oncology, 53(1), 167-176.

Yang, X., Sun, Y., Li, H., Shao, Y., Zhao, D., Yu, W., & Fu, J. (2017). C-terminal binding protein-2 promotes cell proliferation and migration in breast cancer via suppression of p16INK4A. Oncotarget, 8(16), 26154.

Nan, J., Guan, S., Jin, X., Jian, Z., Linshan, F., & Jun, G. (2017). Down-regulation of C-terminal binding protein 2 (CtBP2) inhibits proliferation, migration, and invasion of human SHSY5Y cells in vitro. Neuroscience letters, 647, 104-109.

Sumner, E. T., Chawla, A. T., Cororaton, A. D., Koblinski, J. E., Kovi, R. C., Love, I. M., ... & Grossman, S. R. (2017). Transforming activity and therapeutic targeting of C-terminal-binding protein 2 in Apc-mutated neoplasia. Oncogene, 36(33), 4810-4816.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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