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Mouse Anti-CTBP2 Antibody (2B11) (CBMAB-0252-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
2B11
Antibody Isotype
IgG2b
Application
WB, MA

Basic Information

Immunogen
Recombinant protein
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
C-Terminal Binding Protein 2
Introduction
The CTBP2 gene produces alternative transcripts encoding two distinct proteins. One protein is a transcriptional repressor, while the other isoform is a major component of specialized synapses known as synaptic ribbons. They typically turn their target genes off. They do this by binding to sequence-specific DNA-binding proteins that carry a short motif of the general form Proline-Isoleucine-Aspartate-Leucine-Serine (the PIDLS motif).
Entrez Gene ID
1488
UniProt ID
P56545
Alternative Names
C-Terminal Binding Protein 2; Ribeye; CtBP2
Function
Corepressor targeting diverse transcription regulators. Functions in brown adipose tissue (BAT) differentiation (By similarity).

Isoform 2 probably acts as a scaffold for specialized synapses.
Biological Process
Cellular response to leukemia inhibitory factor Source: Ensembl
Negative regulation of cell population proliferation Source: ProtInc
Negative regulation of transcription, DNA-templated Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: ARUK-UCL
Positive regulation of chromatin binding Source: Ensembl
Positive regulation of retinoic acid receptor signaling pathway Source: MGI
Positive regulation of transcription by RNA polymerase II Source: MGI
Synaptic vesicle docking Source: Ensembl
Viral genome replication Source: ProtInc
White fat cell differentiation Source: UniProtKB
Cellular Location
Nucleus; Synapse
More Infomation

Wang, Q., & Wu, Q. (2022). Knockdown of receptor interacting protein 140 (RIP140) alleviated lipopolysaccharide-induced inflammation, apoptosis and permeability in pulmonary microvascular endothelial cells by regulating C-terminal binding protein 2 (CTBP2). Bioengineered, 13(2), 3981-3992.

Aoyagi, T., Yoshino, R., Mitsuta, Y., Morita, R., Harada, R., & Shigeta, Y. (2022). Integrated In Silico Studies on the Role of Nicotinamide Adenine Dinucleotide (NADH) Binding in Activating C-Terminal Binding Protein 2 (CtBP2). Chemistry Letters, 51(1), 1-4.

Li, B., Xiang, Z., Xiong, F., Yan, B., & Huang, Q. (2020). C-terminal binding protein-2 is a prognostic marker for lung adenocarcinomas. Medicine, 99(31).

Wang, P., Yu, B., Wang, C., & Zhou, S. (2020). C-terminal of E1A binding protein 2 promotes the malignancy of osteosarcoma cells via JAK1/Stat3 signaling. Journal of cell communication and signaling, 14(1), 67-76.

Wang, D. P., Gu, L. L., Xue, Q., Chen, H., & Mao, G. X. (2018). CtBP2 promotes proliferation and reduces drug sensitivity in non-small cell lung cancer via the Wnt/β-catenin pathway. Neoplasma, 65(6), 888-897.

Shi, H., Mao, Y., Ju, Q., Wu, Y., Bai, W., Wang, P., ... & Jiang, M. (2018). C-terminal binding protein‑2 mediates cisplatin chemoresistance in esophageal cancer cells via the inhibition of apoptosis. International journal of oncology, 53(1), 167-176.

Yang, X., Sun, Y., Li, H., Shao, Y., Zhao, D., Yu, W., & Fu, J. (2017). C-terminal binding protein-2 promotes cell proliferation and migration in breast cancer via suppression of p16INK4A. Oncotarget, 8(16), 26154.

Nan, J., Guan, S., Jin, X., Jian, Z., Linshan, F., & Jun, G. (2017). Down-regulation of C-terminal binding protein 2 (CtBP2) inhibits proliferation, migration, and invasion of human SHSY5Y cells in vitro. Neuroscience letters, 647, 104-109.

Sumner, E. T., Chawla, A. T., Cororaton, A. D., Koblinski, J. E., Kovi, R. C., Love, I. M., ... & Grossman, S. R. (2017). Transforming activity and therapeutic targeting of C-terminal-binding protein 2 in Apc-mutated neoplasia. Oncogene, 36(33), 4810-4816.

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For research use only. Not intended for any clinical use.

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