Mouse Anti-CRYZ Recombinant Antibody (2A9DD1) (CBMAB-1451-CN)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

2A9DD1

Antibody Isotype

IgG2a, Κ

Application

IF, IP, ELISA

Basic Information

Immunogen

Tissue, cells or virus corresponding to CRYZ. Human liver mitochondria.

Specificity

Human

Antibody Isotype

IgG2a, Κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

HBS

Preservative

0.02% Sodium azide

Concentration

1 mg/mL

Storage

Store at +4°C. Do not freeze.

Target

Full Name

Crystallin Zeta

Introduction

Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. This gene encodes a taxon-specific crystallin protein which has NADPH-dependent quinone reductase activity distinct from other known quinone reductases. Unlike other mammalian species, in humans, lens expression is low. It binds NADP and acts through a one-electron transfer process.

Entrez Gene ID

1429

UniProt ID

Q08257

Alternative Names

quinone oxidoreductase; NADPH:quinone reductase; crystallin, zeta (quinone reductase); EC 1.6.5.5

Function

Does not have alcohol dehydrogenase activity. Binds NADP and acts through a one-electron transfer process. Orthoquinones, such as 1,2-naphthoquinone or 9,10-phenanthrenequinone, are the best substrates (in vitro). May act in the detoxification of xenobiotics. Interacts with (AU)-rich elements (ARE) in the 3'-UTR of target mRNA species. Enhances the stability of mRNA coding for BCL2. NADPH binding interferes with mRNA binding.

Biological Process

Protein homotetramerization Source: UniProtKB
Visual perception Source: ProtInc
Xenobiotic catabolic process Source: UniProtKB

Cellular Location

Cytoplasm

More Infomation

References

Hashmi, M. A., Malik, A., Arsalan, A., Khan, M. A., & Younus, H. (2021). Elucidation of kinetic and structural properties of eye lens ζ-crystallin: an in vitro and in silico approach. Journal of Biomolecular Structure and Dynamics, 1-15.

Abdullah, E. M., Haq, S. H., Ahmed, M. A., Khan, J. M., Alamery, S. F., & Malik, A. (2020). Structural stability and solubility of glycated camel lens ζ-crystallin. International Journal of Biological Macromolecules, 158, 384-393.

Lulli, M., Nencioni, D., Papucci, L., & Schiavone, N. (2020). Zeta-crystallin: a moonlighting player in cancer. Cellular and Molecular Life Sciences, 77(6), 965-976.

Alam, G., Luan, Z., Gul, A., Lu, H., Zhou, Y., Huo, X., ... & Zhang, X. (2020). Activation of farnesoid X receptor (FXR) induces crystallin zeta expression in mouse medullary collecting duct cells. Pflügers Archiv-European Journal of Physiology, 472(11), 1631-1641.

Wei, L., Tian, Y., Chen, Y., Wei, Q., Chen, F., Cao, B., ... & Wang, K. (2019). Identification of TYW3/CRYZ and FGD4 as susceptibility genes for amyotrophic lateral sclerosis. Neurology Genetics, 5(6).

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Related Products

Rabbit Anti-CRYZ Recombinant Antibody (CBWJC-3150)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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SDS
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