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Rabbit Anti-CORO1A Recombinant Antibody (D6K5B) (CBMAB-CP0351-LY)


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Summary

Host Animal
Rabbit
Specificity
Human, Mouse
Clone
D6K5B
Antibody Isotype
IgG
Application
WB, IHC-P, FC

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val200 of human coronin 1A protein.
Specificity
Human, Mouse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Coronin 1A
Introduction
CORO1A (Coronin 1A) is a Protein Coding gene. Diseases associated with CORO1A include Immunodeficiency 8 and Coronin-1A Deficiency. Among its related pathways are Phagosome and Cytoskeletal Signaling. Gene Ontology (GO) annotations related to this gene include identical protein binding. An important paralog of this gene is CORO1B.
Entrez Gene ID
Human11151
Mouse12721
UniProt ID
HumanP31146
MouseO89053
Alternative Names
Coronin 1A; Tryptophan Aspartate-Containing Coat Protein; Coronin-Like Protein P57; Coronin-Like Protein A; Clipin-A; TACO; Coronin; Actin-Binding Protein; 1A; Coronin; Actin Binding Protein; 1A; Clabp TACO;
Function
May be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion. In mycobacteria-infected cells, its retention on the phagosomal membrane prevents fusion between phagosomes and lysosomes.
Biological Process
Actin cytoskeleton organization Source: UniProtKB
Actin filament organization Source: GO_Central
Calcium ion transport Source: Ensembl
Cell migration Source: GO_Central
Cell-substrate adhesion Source: UniProtKB
Cellular response to interleukin-4 Source: Ensembl
Early endosome to recycling endosome transport Source: Ensembl
Homeostasis of number of cells within a tissue Source: Ensembl
Innate immune response Source: UniProtKB
Leukocyte chemotaxis Source: Ensembl
Natural killer cell degranulation Source: UniProtKB
Negative regulation of actin nucleation Source: UniProtKB
Negative regulation of neuron apoptotic process Source: Ensembl
Negative regulation of vesicle fusion Source: Ensembl
Nerve growth factor signaling pathway Source: Ensembl
Phagocytosis Source: UniProtKB
Phagolysosome assembly Source: UniProtKB
Positive chemotaxis Source: UniProtKB
Positive regulation of cell migration Source: Ensembl
Positive regulation of T cell proliferation Source: Ensembl
Regulation of actin cytoskeleton organization Source: UniProtKB
Regulation of cell shape Source: Ensembl
Regulation of release of sequestered calcium ion into cytosol Source: Ensembl
T cell homeostasis Source: Ensembl
Uropod organization Source: Ensembl
Cellular Location
Cytoskeleton; Cell cortex; Phagosome membrane. In non-infected macrophages, associated with the cortical microtubule network. In mycobacteria-infected macrophages, becomes progressively relocalized and retained around the mycobacterial phagosomes. Retention on the phagosomal membrane is strictly dependent on mycobacterial viability and not due to impaired acidification (By similarity).
Involvement in disease
Immunodeficiency 8 (IMD8):
A disease of the immune system leading to recurrent infections, and characterized by CD4+ T-cells lymphopenia. Patients can develop B-cell lymphoproliferation associated with Epstein-Barr virus infection.
PTM
phosphorylation at Thr-412 by PKC strongly down-regulates the association with actin.
Polyubiquitinated by RNF128 with 'Lys-48'-linked chains, leading to proteasomal degradation.
More Infomation

Wang, Y., Li, T., Li, H., Liang, Y., Mai, W., Liu, C., ... & Zhang, Q. (2022). CORO1A regulates lipoprotein uptake in Leydig cells exposed to cadmium. Ecotoxicology and Environmental Safety, 232, 113255.

Pandey, H. S., Kapoor, R., & Seth, P. (2020). Coronin 1A Expression in Human Astroglia, its Function in Physiology and Astrogliosis in HIV-1 Neuropathogenesis.

Nicolaou, O., Sokratous, K., Makowska, Z., Morell, M., De Groof, A., Montigny, P., ... & Kyriacou, K. (2020). Proteomic analysis in lupus mice identifies Coronin-1A as a potential biomarker for lupus nephritis. Arthritis research & therapy, 22(1), 1-16.

Riley, D. R., Khalil, J. S., Pieters, J., Naseem, K. M., & Rivero, F. (2020). Coronin 1 is required for integrin β2 translocation in platelets. International journal of molecular sciences, 21(1), 356.

Feng, J., Chen, S., Wang, Y., Liu, Q., Yang, M., Li, X., ... & Zhang, Q. (2019). Maternal exposure to cadmium impairs cognitive development of male offspring by targeting the Coronin-1a signaling pathway. Chemosphere, 225, 765-774.

Ford, M. L. (2019). Coronin-1, king of alloimmunity. Immunity, 50(1), 3-5.

Jayachandran, R., Gumienny, A., Bolinger, B., Ruehl, S., Lang, M. J., Fucile, G., ... & Pieters, J. (2019). Disruption of coronin 1 signaling in T cells promotes allograft tolerance while maintaining anti-pathogen immunity. Immunity, 50(1), 152-165.

Stocker, T. J., Pircher, J., Skenderi, A., Ehrlich, A., Eberle, C., Megens, R. T., ... & Schulz, C. (2018). The actin regulator coronin-1A modulates platelet shape change and consolidates arterial thrombosis. Thrombosis and haemostasis, 118(12), 2098-2111.

Pick, R., Begandt, D., Stocker, T. J., Salvermoser, M., Thome, S., Böttcher, R. T., ... & Walzog, B. (2017). Coronin 1A, a novel player in integrin biology, controls neutrophil trafficking in innate immunity. Blood, The Journal of the American Society of Hematology, 130(7), 847-858.

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For research use only. Not intended for any clinical use.

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