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Mouse Anti-CORO1A Monoclonal Antibody (1A5) (CBMAB-0971-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
1A5
Antibody Isotype
IgG1
Application
FC, ICC, IF, WB

Basic Information

Immunogen
Full length human recombinant protein of CORO1A(NP_009005) produced in HEK293T cell
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
>95%, as determined by SDS-PAGE analysis
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Coronin 1A
Introduction
Coronin 1A is a member of the WD repeat protein family, whcih are minimally conserved regions and may facilitate formation of heterotrimeric or multiprotein complexes. Coronin 1A may be involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation.
Entrez Gene ID
11151
UniProt ID
P31146
Alternative Names
p57; IMD8; TACO; CLABP; HCORO1; CLIPINA
Function
May be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion. In mycobacteria-infected cells, its retention on the phagosomal membrane prevents fusion between phagosomes and lysosomes.
Biological Process
Actin cytoskeleton organization Source: UniProtKB
Actin filament organization Source: GO_Central
Calcium ion transport Source: Ensembl
Cell migration Source: GO_Central
Cell-substrate adhesion Source: UniProtKB
Cellular response to interleukin-4 Source: Ensembl
Early endosome to recycling endosome transport Source: Ensembl
Homeostasis of number of cells within a tissue Source: Ensembl
Innate immune response Source: UniProtKB
Leukocyte chemotaxis Source: Ensembl
Natural killer cell degranulation Source: UniProtKB
Negative regulation of actin nucleation Source: UniProtKB
Negative regulation of neuron apoptotic process Source: Ensembl
Negative regulation of vesicle fusion Source: Ensembl
Nerve growth factor signaling pathway Source: Ensembl
Phagocytosis Source: UniProtKB
Phagolysosome assembly Source: UniProtKB
Positive chemotaxis Source: UniProtKB
Positive regulation of cell migration Source: Ensembl
Positive regulation of T cell proliferation Source: Ensembl
Regulation of actin cytoskeleton organization Source: UniProtKB
Regulation of cell shape Source: Ensembl
Regulation of release of sequestered calcium ion into cytosol Source: Ensembl
T cell homeostasis Source: Ensembl
Uropod organization Source: Ensembl
Cellular Location
Cytoskeleton; Cell cortex; Phagosome membrane. In non-infected macrophages, associated with the cortical microtubule network. In mycobacteria-infected macrophages, becomes progressively relocalized and retained around the mycobacterial phagosomes. Retention on the phagosomal membrane is strictly dependent on mycobacterial viability and not due to impaired acidification (By similarity).
Involvement in disease
Immunodeficiency 8 (IMD8):
A disease of the immune system leading to recurrent infections, and characterized by CD4+ T-cells lymphopenia. Patients can develop B-cell lymphoproliferation associated with Epstein-Barr virus infection.
PTM
phosphorylation at Thr-412 by PKC strongly down-regulates the association with actin.
Polyubiquitinated by RNF128 with 'Lys-48'-linked chains, leading to proteasomal degradation.
More Infomation

Wang, Y., Li, T., Li, H., Liang, Y., Mai, W., Liu, C., ... & Zhang, Q. (2022). CORO1A regulates lipoprotein uptake in Leydig cells exposed to cadmium. Ecotoxicology and Environmental Safety, 232, 113255.

Pandey, H. S., Kapoor, R., & Seth, P. (2020). Coronin 1A Expression in Human Astroglia, its Function in Physiology and Astrogliosis in HIV-1 Neuropathogenesis.

Nicolaou, O., Sokratous, K., Makowska, Z., Morell, M., De Groof, A., Montigny, P., ... & Kyriacou, K. (2020). Proteomic analysis in lupus mice identifies Coronin-1A as a potential biomarker for lupus nephritis. Arthritis research & therapy, 22(1), 1-16.

Riley, D. R., Khalil, J. S., Pieters, J., Naseem, K. M., & Rivero, F. (2020). Coronin 1 is required for integrin β2 translocation in platelets. International journal of molecular sciences, 21(1), 356.

Feng, J., Chen, S., Wang, Y., Liu, Q., Yang, M., Li, X., ... & Zhang, Q. (2019). Maternal exposure to cadmium impairs cognitive development of male offspring by targeting the Coronin-1a signaling pathway. Chemosphere, 225, 765-774.

Ford, M. L. (2019). Coronin-1, king of alloimmunity. Immunity, 50(1), 3-5.

Jayachandran, R., Gumienny, A., Bolinger, B., Ruehl, S., Lang, M. J., Fucile, G., ... & Pieters, J. (2019). Disruption of coronin 1 signaling in T cells promotes allograft tolerance while maintaining anti-pathogen immunity. Immunity, 50(1), 152-165.

Stocker, T. J., Pircher, J., Skenderi, A., Ehrlich, A., Eberle, C., Megens, R. T., ... & Schulz, C. (2018). The actin regulator coronin-1A modulates platelet shape change and consolidates arterial thrombosis. Thrombosis and haemostasis, 118(12), 2098-2111.

Pick, R., Begandt, D., Stocker, T. J., Salvermoser, M., Thome, S., Böttcher, R. T., ... & Walzog, B. (2017). Coronin 1A, a novel player in integrin biology, controls neutrophil trafficking in innate immunity. Blood, The Journal of the American Society of Hematology, 130(7), 847-858.

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For research use only. Not intended for any clinical use.

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