CORO1A

CORO1A (Coronin 1A) is a Protein Coding gene. Diseases associated with CORO1A include Immunodeficiency 8 and Coronin-1A Deficiency. Among its related pathways are Phagosome and Cytoskeletal Signaling. Gene Ontology (GO) annotations related to this gene include identical protein binding. An important paralog of this gene is CORO1B.

Coronin 1A

May be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion. In mycobacteria-infected cells, its retention on the phagosomal membrane prevents fusion between phagosomes and lysosomes.

Actin cytoskeleton organization Source: UniProtKB
Actin filament organization Source: GO_Central
Calcium ion transport Source: Ensembl
Cell migration Source: GO_Central
Cell-substrate adhesion Source: UniProtKB
Cellular response to interleukin-4 Source: Ensembl
Early endosome to recycling endosome transport Source: Ensembl
Homeostasis of number of cells within a tissue Source: Ensembl
Innate immune response Source: UniProtKB
Leukocyte chemotaxis Source: Ensembl
Natural killer cell degranulation Source: UniProtKB
Negative regulation of actin nucleation Source: UniProtKB
Negative regulation of neuron apoptotic process Source: Ensembl
Negative regulation of vesicle fusion Source: Ensembl
Nerve growth factor signaling pathway Source: Ensembl
Phagocytosis Source: UniProtKB
Phagolysosome assembly Source: UniProtKB
Positive chemotaxis Source: UniProtKB
Positive regulation of cell migration Source: Ensembl
Positive regulation of T cell proliferation Source: Ensembl
Regulation of actin cytoskeleton organization Source: UniProtKB
Regulation of cell shape Source: Ensembl
Regulation of release of sequestered calcium ion into cytosol Source: Ensembl
T cell homeostasis Source: Ensembl
Uropod organization Source: Ensembl

Cytoskeleton; Cell cortex; Phagosome membrane. In non-infected macrophages, associated with the cortical microtubule network. In mycobacteria-infected macrophages, becomes progressively relocalized and retained around the mycobacterial phagosomes. Retention on the phagosomal membrane is strictly dependent on mycobacterial viability and not due to impaired acidification (By similarity).

Immunodeficiency 8 (IMD8):
A disease of the immune system leading to recurrent infections, and characterized by CD4+ T-cells lymphopenia. Patients can develop B-cell lymphoproliferation associated with Epstein-Barr virus infection.

phosphorylation at Thr-412 by PKC strongly down-regulates the association with actin.
Polyubiquitinated by RNF128 with 'Lys-48'-linked chains, leading to proteasomal degradation.