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Mouse Anti-CNTF Recombinant Antibody (CBYY-C0033) (V2LY-1206-LY516)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBYY-C0033
Antibody Isotype
IgG2a, κ
Application
WB, IP, IF, ELISA

Basic Information

Immunogen
Amino acids 171-197 at the C-terminus of CNTF of rat.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500
ELISA1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
0.1% gelatin
Preservative
<0.1% sodium azide
Concentration
0.2 mg/ml
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Ciliary Neurotrophic Factor
Entrez Gene ID
Human1270
Mouse12803
Rat25707
UniProt ID
HumanP26441
MouseP51642
RatP20294
Function
CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.
Biological Process
Astrocyte activation Source: GO_Central
Ciliary neurotrophic factor-mediated signaling pathway Source: BHF-UCL
Cytokine-mediated signaling pathway Source: Reactome
Muscle organ morphogenesis Source: Ensembl
Negative regulation of neuron apoptotic process Source: BHF-UCL
Negative regulation of photoreceptor cell differentiation Source: Ensembl
Neuron development Source: Ensembl
Positive regulation of axon regeneration Source: GO_Central
Positive regulation of cell population proliferation Source: GO_Central
Positive regulation of gene expression Source: MGI
Positive regulation of tyrosine phosphorylation of STAT protein Source: BHF-UCL
Regulation of retinal cell programmed cell death Source: Ensembl
Signal transduction Source: ProtInc
Cellular Location
Cytoplasm
More Infomation

Wang, Y., Rhee, K. D., Pellegrini, M., & Yang, X. J. (2020). Impacts of ciliary neurotrophic factor on the retinal transcriptome in a mouse model of photoreceptor degeneration. Scientific reports, 10(1), 1-11.

Chew, E. Y., Clemons, T. E., Jaffe, G. J., Johnson, C. A., Farsiu, S., Lad, E. M., ... & Phase 2 CNTF Research Group. (2019). Effect of ciliary neurotrophic factor on retinal neurodegeneration in patients with macular telangiectasia type 2: a randomized clinical trial. Ophthalmology, 126(4), 540-549.

Jia, C., Brown, R. W., Malone, H. M., Burgess, K. C., Gill, W. D., Keasey, M. P., & Hagg, T. (2019). Ciliary neurotrophic factor is a key sex-specific regulator of depressive-like behavior in mice. Psychoneuroendocrinology, 100, 96-105.

Ghasemi, M., Alizadeh, E., Saei Arezoumand, K., Fallahi Motlagh, B., & Zarghami, N. (2018). Ciliary neurotrophic factor (CNTF) delivery to retina: an overview of current research advancements. Artificial cells, nanomedicine, and biotechnology, 46(8), 1694-1707.

Li, S., Sato, K., Gordon, W. C., Sendtner, M., Bazan, N. G., & Jin, M. (2018). Ciliary neurotrophic factor (CNTF) protects retinal cone and rod photoreceptors by suppressing excessive formation of the visual pigments. Journal of Biological Chemistry, 293(39), 15256-15268.

Zheng, K., Zhang, Q., Sheng, Z., Li, Y., & Lu, H. H. (2018). Ciliary neurotrophic factor (CNTF) protects myocardial cells from oxygen glucose deprivation (OGD)/re-oxygenation via activation of Akt-Nrf2 signaling. Cellular Physiology and Biochemistry, 51(4), 1852-1862.

Baek, J. Y., Jeong, J. Y., Kim, K. I., Won, S. Y., Chung, Y. C., Nam, J. H., ... & Jin, B. K. (2018). Inhibition of microglia-derived oxidative stress by ciliary neurotrophic factor protects dopamine neurons in vivo from MPP+ neurotoxicity. International journal of molecular sciences, 19(11), 3543.

Ma, M., Xu, Y., Xiong, S., Zhang, J., Gu, Q., Ke, B., & Xu, X. (2018). Involvement of ciliary neurotrophic factor in early diabetic retinal neuropathy in streptozotocin-induced diabetic rats. Eye, 32(9), 1463-1471.

Shpak, A. A., Guekht, A. B., Druzhkova, T. A., Kozlova, K. I., & Gulyaeva, N. V. (2017). Ciliary neurotrophic factor in patients with primary open-angle glaucoma and age-related cataract. Molecular vision, 23, 799.

Fan, L., Xiong, Y., Fu, Z., Xu, D., Wang, L., Chen, Y., ... & Ye, Q. (2017). Polyaniline promotes peripheral nerve regeneration by enhancement of the brain‑derived neurotrophic factor and ciliary neurotrophic factor expression and activation of the ERK1/2/MAPK signaling pathway. Molecular medicine reports, 16(5), 7534-7540.

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For research use only. Not intended for any clinical use.

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