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Mouse Anti-CNTF Recombinant Antibody (C4008) (V2LY-1206-LY520)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
C4008
Antibody Isotype
IgG1
Application
ELISA, IP, WB

Basic Information

Immunogen
Human CNTF.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
0.08% sodium azide
Concentration
1 mg/ml
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Ciliary Neurotrophic Factor
Entrez Gene ID
1270
UniProt ID
P26441
Function
CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.
Biological Process
Astrocyte activation Source: GO_Central
Ciliary neurotrophic factor-mediated signaling pathway Source: BHF-UCL
Cytokine-mediated signaling pathway Source: Reactome
Muscle organ morphogenesis Source: Ensembl
Negative regulation of neuron apoptotic process Source: BHF-UCL
Negative regulation of photoreceptor cell differentiation Source: Ensembl
Neuron development Source: Ensembl
Positive regulation of axon regeneration Source: GO_Central
Positive regulation of cell population proliferation Source: GO_Central
Positive regulation of gene expression Source: MGI
Positive regulation of tyrosine phosphorylation of STAT protein Source: BHF-UCL
Regulation of retinal cell programmed cell death Source: Ensembl
Signal transduction Source: ProtInc
Cellular Location
Cytoplasm
More Infomation

Wang, Y., Rhee, K. D., Pellegrini, M., & Yang, X. J. (2020). Impacts of ciliary neurotrophic factor on the retinal transcriptome in a mouse model of photoreceptor degeneration. Scientific reports, 10(1), 1-11.

Chew, E. Y., Clemons, T. E., Jaffe, G. J., Johnson, C. A., Farsiu, S., Lad, E. M., ... & Phase 2 CNTF Research Group. (2019). Effect of ciliary neurotrophic factor on retinal neurodegeneration in patients with macular telangiectasia type 2: a randomized clinical trial. Ophthalmology, 126(4), 540-549.

Jia, C., Brown, R. W., Malone, H. M., Burgess, K. C., Gill, W. D., Keasey, M. P., & Hagg, T. (2019). Ciliary neurotrophic factor is a key sex-specific regulator of depressive-like behavior in mice. Psychoneuroendocrinology, 100, 96-105.

Ghasemi, M., Alizadeh, E., Saei Arezoumand, K., Fallahi Motlagh, B., & Zarghami, N. (2018). Ciliary neurotrophic factor (CNTF) delivery to retina: an overview of current research advancements. Artificial cells, nanomedicine, and biotechnology, 46(8), 1694-1707.

Li, S., Sato, K., Gordon, W. C., Sendtner, M., Bazan, N. G., & Jin, M. (2018). Ciliary neurotrophic factor (CNTF) protects retinal cone and rod photoreceptors by suppressing excessive formation of the visual pigments. Journal of Biological Chemistry, 293(39), 15256-15268.

Zheng, K., Zhang, Q., Sheng, Z., Li, Y., & Lu, H. H. (2018). Ciliary neurotrophic factor (CNTF) protects myocardial cells from oxygen glucose deprivation (OGD)/re-oxygenation via activation of Akt-Nrf2 signaling. Cellular Physiology and Biochemistry, 51(4), 1852-1862.

Baek, J. Y., Jeong, J. Y., Kim, K. I., Won, S. Y., Chung, Y. C., Nam, J. H., ... & Jin, B. K. (2018). Inhibition of microglia-derived oxidative stress by ciliary neurotrophic factor protects dopamine neurons in vivo from MPP+ neurotoxicity. International journal of molecular sciences, 19(11), 3543.

Ma, M., Xu, Y., Xiong, S., Zhang, J., Gu, Q., Ke, B., & Xu, X. (2018). Involvement of ciliary neurotrophic factor in early diabetic retinal neuropathy in streptozotocin-induced diabetic rats. Eye, 32(9), 1463-1471.

Shpak, A. A., Guekht, A. B., Druzhkova, T. A., Kozlova, K. I., & Gulyaeva, N. V. (2017). Ciliary neurotrophic factor in patients with primary open-angle glaucoma and age-related cataract. Molecular vision, 23, 799.

Fan, L., Xiong, Y., Fu, Z., Xu, D., Wang, L., Chen, Y., ... & Ye, Q. (2017). Polyaniline promotes peripheral nerve regeneration by enhancement of the brain‑derived neurotrophic factor and ciliary neurotrophic factor expression and activation of the ERK1/2/MAPK signaling pathway. Molecular medicine reports, 16(5), 7534-7540.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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