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Mouse Anti-CLTA Recombinant Antibody (3F133) (CBMAB-C0338-YY)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat, Zebrafish, Cattle
Clone
3F133
Antibody Isotype
IgG2b
Application
ICC, IF, IHC-P, IP, WB

Basic Information

Immunogen
Synthetic peptide: EEDPAAAFLAQQESEIAGIEND, corresponding to amino acids 23-44 of the conserved regions of Cow Clathrin Light Chain
Specificity
Human, Mouse, Rat, Zebrafish, Cattle
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Protein A purified
Buffer
1 mg/mL
Preservative
PBS
Concentration
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
clathrin, light chain (Lca)
Entrez Gene ID
Human1211
Mouse12757
Rat83800
Cattle281078
Zebrafish406318
UniProt ID
HumanP09496
MouseO08585
RatP08081
CattleP04973
ZebrafishQ6P937
Alternative Names
C-X-C Motif Chemokine Ligand 2; Macrophage Inflammatory Protein 2-Alpha; Chemokine (C-X-C Motif) Ligand 2; Growth-Regulated Protein Beta; GRO2 Oncogene; MIP2-Alpha; Gro-Beta; MIP2A; SCYB2; GROb;
Function
Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge (PubMed:15858577, PubMed:21297582).
Biological Process
Antigen processing and presentation of exogenous peptide antigen via MHC class II Source: Reactome
Cell cycle Source: UniProtKB-KW
Cell division Source: UniProtKB-KW
Clathrin coat assembly Source: CAFA
Clathrin-dependent endocytosis Source: GO_Central
Intracellular protein transport Source: InterPro
Low-density lipoprotein particle clearance Source: Reactome
Low-density lipoprotein particle receptor catabolic process Source: Reactome
Membrane organization Source: Reactome
Post-Golgi vesicle-mediated transport Source: Reactome
Cellular Location
Spindle; Cytoplasmic vesicle membrane; Coated pit. Cytoplasmic face of coated pits and vesicles. In complex with TACC3 and CKAP5 (forming the TACC3/ch-TOG/clathrin complex) localized to inter-microtubule bridges in mitotic spindles.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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