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Mouse Anti-CHAT Recombinant Antibody (CBLNC-155) (CBMAB-1354-CN)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBLNC-155
Antibody Isotype
IgG1, κ
Application
ELISA, IF, IP, WB, IHC-P

Basic Information

Immunogen
Choactase of human.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1, κ
Clonality
Monoclonal Antibody
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500
ELISA1:100-1:1,000
IHC-P1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
< 0.1% sodium azide
Concentration
0.2 mg/ml
Storage
Store at +4°C.

Target

Full Name
ChAT
Introduction
Choline O-acetyltransferase (CHAT) catalyzes the biosynthesis of the neurotransmitter acetylcholine. CHAT is a characteristic feature of cholinergic neurons, and changes in these neurons may explain some of the symptoms of Alzheimer's disease. Mutations in CHAT gene are associated with congenital myasthenic syndrome associated with episodic apnea, Alzheimer's disease and mild cognitive impairment.
Entrez Gene ID
Human1103
Monkey709977
Rat290567
Guinea pig100718930
UniProt ID
HumanP28329
MonkeyA0A2K5VTI9
RatP32738
Guinea pigH0V586
Alternative Names
CMS6; CMS1A; CMS1A2; CHOACTASE
Function
Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses.
Biological Process
Acetylcholine biosynthetic process Source: GO_Central
Neuromuscular synaptic transmission Source: GO_Central
Neurotransmitter transport Source: Reactome
Phosphatidylcholine biosynthetic process Source: Reactome
Cellular Location
Cytosol; Nucleus; Cytoplasm; Neuron projection; Synapse
Involvement in disease
Myasthenic syndrome, congenital, 6, presynaptic (CMS6): A form of congenital myasthenic syndrome, a group of disorders characterized by failure of neuromuscular transmission, including pre-synaptic, synaptic, and post-synaptic disorders that are not of autoimmune origin. Clinical features are easy fatigability and muscle weakness affecting the axial and limb muscles (with hypotonia in early-onset forms), the ocular muscles (leading to ptosis and ophthalmoplegia), and the facial and bulbar musculature (affecting sucking and swallowing, and leading to dysphonia). The symptoms fluctuate and worsen with physical effort. CMS6 affected individuals have myasthenic symptoms since birth or early infancy, negative tests for anti-AChR antibodies, and abrupt episodic crises with increased weakness, bulbar paralysis, and apnea precipitated by undue exertion, fever, or excitement. CMS6 inheritance is autosomal recessive.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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