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Rabbit Anti-CHAT Recombinant Antibody (CBFYC-1803) (CBMAB-C1865-FY)


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Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
CBFYC-1803
Antibody Isotype
IgG
Application
WB, IHC, IF

Basic Information

Immunogen
Recombinant protein encompassing a sequence within the N-terminus region of human Choline Acetyltransferase..
Host Species
Rabbit
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal Antibody
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:500-1:3,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
None
Concentration
1 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
ChAT
Introduction
Biased expression in Brain (RPKM 10.4) and Testes (RPKM 4.3).
Entrez Gene ID
Rat290567
Chicken395314
UniProt ID
RatP32738
ChickenQ90YJ9
Alternative Names
choline O-acetyltransferase; CHOACTase; choline acetylase; choline acetyltransferase; EC 2.3.1.6
Function
Catalyzes the reversible synthesis of acetylcholine (ACh) from acetyl CoA and choline at cholinergic synapses.
Biological Process
Acetylcholine biosynthetic process Source: GO_Central
Neuromuscular synaptic transmission Source: GO_Central
Neurotransmitter transport Source: Reactome
Phosphatidylcholine biosynthetic process Source: Reactome
Cellular Location
Cytosol; Nucleus; Cytoplasm; Neuron projection; Synapse
Involvement in disease
Myasthenic syndrome, congenital, 6, presynaptic (CMS6): A form of congenital myasthenic syndrome, a group of disorders characterized by failure of neuromuscular transmission, including pre-synaptic, synaptic, and post-synaptic disorders that are not of autoimmune origin. Clinical features are easy fatigability and muscle weakness affecting the axial and limb muscles (with hypotonia in early-onset forms), the ocular muscles (leading to ptosis and ophthalmoplegia), and the facial and bulbar musculature (affecting sucking and swallowing, and leading to dysphonia). The symptoms fluctuate and worsen with physical effort. CMS6 affected individuals have myasthenic symptoms since birth or early infancy, negative tests for anti-AChR antibodies, and abrupt episodic crises with increased weakness, bulbar paralysis, and apnea precipitated by undue exertion, fever, or excitement. CMS6 inheritance is autosomal recessive.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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