Rabbit Anti-CEACAM16 Recombinant Antibody (C10865) (CBMAB-C10865-LY)

See all CEACAM16 antibodies

Online Inquiry

Datasheet

Summary

Host Animal

Rabbit

Specificity

Human

Clone

C10865

Antibody Isotype

IgG

Application

FC, IF

Basic Information

Immunogen

Chinese Hamster Ovary cell line CHO-derived human CEACAM-16 Met1-Gly425.

Host Species

Rabbit

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal Antibody

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
IF(ICC)	3-25 µg/ml
FC	0.25 µg/10^6 cells

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Buffer

PBS, 5% trehalose

Preservative

None

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

Carcinoembryonic Antigen Related Cell Adhesion Molecule 16

Introduction

The protein encoded by this gene is a secreted glycoprotein that in mouse interacts with tectorial membrane proteins in the inner ear. The encoded adhesion protein is found in cochlear outer hair cells and appears to be important for proper hearing over an extended frequency range. Defects in this gene likely are a cause of non-syndromic autosomal dominant hearing loss. [provided by RefSeq, May 2012]

Entrez Gene ID

388551

UniProt ID

Q2WEN9

Alternative Names

Carcinoembryonic Antigen Related Cell Adhesion Molecule 16; Carcinoembryonic Antigen-Related Cell Adhesion Molecule 16; CEAL2; Carcinoembryonic Antigen Like-2 Protein; Carcinoembryonic Antigen-Like 2; DFNA4B;

Function

Required for proper hearing, plays a role in maintaining the integrity of the tectorial membrane.

Biological Process

Sensory perception of sound Source: UniProtKB

Cellular Location

Secreted. Localizes to the tip of cochlear outer hair cells and to the tectorial membrane.

Involvement in disease

Deafness, autosomal dominant, 4B (DFNA4B): A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
Deafness, autosomal recessive, 113 (DFNB113): A form of non-syndromic, sensorineural deafness characterized by postlingual progressive hearing impairment. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.

More Infomation

References

Mansour, A., Sellon, J. B., Filizzola, D., Ghaffari, R., Cheatham, M. A., & Freeman, D. M. (2021). Age-related degradation of tectorial membrane dynamics with loss of CEACAM16. Biophysical Journal, 120(21), 4777-4785.

Dias, A. M. M., Lezirovitz, K., Nicastro, F. S., Mendes, B. C., & Mingroni-Netto, R. C. (2019). Further evidence for loss-of-function mutations in the CEACAM16 gene causing nonsyndromic autosomal recessive hearing loss in humans. Journal of human genetics, 64(3), 257-260.

Booth, K. T., Kahrizi, K., Najmabadi, H., Azaiez, H., & Smith, R. J. (2018). Old gene, new phenotype: splice-altering variants in CEACAM16 cause recessive non-syndromic hearing impairment. Journal of medical genetics, 55(8), 555-560.

Q & As

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Review & reward

Have you used Rabbit Anti-CEACAM16 Recombinant Antibody (C10865)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Related Products

Mouse Anti-CEACAM16 Recombinant Antibody (CBFYC-1676)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Datasheet
SDS
Request for COA

Request bulk or custom quote Online Inquiry
Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email: