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Mouse Anti-CEACAM16 Recombinant Antibody (CBFYC-1676) (CBMAB-C1738-FY)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBFYC-1676
Antibody Isotype
IgG1, κ
Application
WB, IF, ELISA, IP

Basic Information

Immunogen
Amino acids 317-380 mapping near the C-terminus of CEACAM16 of human.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1, κ
Clonality
Monoclonal Antibody
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500
ELISA1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
< 0.1% sodium azide
Concentration
0.2 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Carcinoembryonic Antigen Related Cell Adhesion Molecule 16
Introduction
The protein encoded by this gene is a secreted glycoprotein that in mouse interacts with tectorial membrane proteins in the inner ear. The encoded adhesion protein is found in cochlear outer hair cells and appears to be important for proper hearing over an extended frequency range. Defects in this gene likely are a cause of non-syndromic autosomal dominant hearing loss.
Entrez Gene ID
388551
UniProt ID
Q2WEN9
Alternative Names
Carcinoembryonic Antigen Related Cell Adhesion Molecule 16; Carcinoembryonic Antigen-Related Cell Adhesion Molecule 16; CEAL2; Carcinoembryonic Antigen Like-2 Protein; Carcinoembryonic Antigen-Like 2; DFNA4B
Function
Required for proper hearing, plays a role in maintaining the integrity of the tectorial membrane.
Biological Process
Sensory perception of sound Source: UniProtKB
Cellular Location
Secreted. Localizes to the tip of cochlear outer hair cells and to the tectorial membrane.
Involvement in disease
Deafness, autosomal dominant, 4B (DFNA4B): A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
Deafness, autosomal recessive, 113 (DFNB113): A form of non-syndromic, sensorineural deafness characterized by postlingual progressive hearing impairment. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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