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Rat Anti-CD248 Recombinant Antibody (CBXC-1509) (CBMAB-C3606-CQ)


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Summary

Host Animal
Rat
Specificity
Mouse
Clone
CBXC-1509
Antibody Isotype
IgG2a
Application
ICC

Basic Information

Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse Endosialin/CD248 Val13-Arg693.
Host Species
Rat
Specificity
Mouse
Antibody Isotype
IgG2a
Clonality
Monoclonal Antibody
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
IF(ICC)8-25 µg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS, Trehalose
Preservative
None
Concentration
LYOPH
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
CD248 Molecule
Introduction
CD248 (CD248 Molecule) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include calcium ion binding and extracellular matrix binding. An important paralog of this gene is CD93.
Entrez Gene ID
70445
UniProt ID
Q91V98
Function
May play a role in tumor angiogenesis.
Biological Process
Anatomical structure regression Source: Ensembl
Cell migration Source: GO_Central
Lymph node development Source: Ensembl
Positive regulation of cell population proliferation Source: Ensembl
Positive regulation of endothelial cell apoptotic process Source: Ensembl
Cellular Location
Membrane
Topology
Extracellular: 18-687
Helical: 688-708
Cytoplasmic: 709-757
PTM
O-glycosylated with sialylated oligosaccharides.
May be N-glycosylated.
More Infomation

Zhang, K., Xu, C., Liu, S., Jiang, Y., Zhao, X., Ma, S., ... & Qin, W. (2021). The Diagnostic and Immunotherapeutic Value of CD248 in Renal Cell Carcinoma. Frontiers in oncology, 11, 510.

Armitage, E. G., Barnes, A., Patrick, K., Bechar, J., Harrison, M. J., Lavery, G. G., ... & Naylor, A. J. (2021). Metabolic consequences for mice lacking Endosialin: LC–MS/MS-based metabolic phenotyping of serum from C56Bl/6J Control and CD248 knock‐out mice. Metabolomics, 17(2), 1-11.

Matsushima, S., Aoshima, Y., Akamatsu, T., Enomoto, Y., Meguro, S., Kosugi, I., ... & Iwashita, T. (2020). CD248 and integrin alpha-8 are candidate markers for differentiating lung fibroblast subtypes. BMC pulmonary medicine, 20(1), 1-15.

Park, G. B., Jeong, J. Y., & Kim, D. (2020). Modified TLR‐mediated downregulation of miR‐125b‐5p enhances CD248 (endosialin)‐induced metastasis and drug resistance in colorectal cancer cells. Molecular carcinogenesis, 59(2), 154-167.

Di Benedetto, P., Ruscitti, P., Liakouli, V., Del Galdo, F., Giacomelli, R., & Cipriani, P. (2019). Linking myofibroblast generation and microvascular alteration: the role of CD248 from pathogenesis to therapeutic target. Molecular medicine reports, 20(2), 1488-1498.

Teicher, B. A. (2019). CD248: A therapeutic target in cancer and fibrotic diseases. Oncotarget, 10(9), 993.

Petrus, P., Fernandez, T. L., Kwon, M. M., Huang, J. L., Lei, V., Safikhan, N. S., ... & Conway, E. M. (2019). Specific loss of adipocyte CD248 improves metabolic health via reduced white adipose tissue hypoxia, fibrosis and inflammation. EBioMedicine, 44, 489-501.

Di Benedetto, P., Liakouli, V., Ruscitti, P., Berardicurti, O., Carubbi, F., Panzera, N., ... & Giacomelli, R. (2018). Blocking CD248 molecules in perivascular stromal cells of patients with systemic sclerosis strongly inhibits their differentiation toward myofibroblasts and proliferation: a new potential target for antifibrotic therapy. Arthritis research & therapy, 20(1), 1-12.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

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