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Mouse Anti-CD248 Recombinant Antibody (C6683) (CBMAB-C6683-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
C6683
Antibody Isotype
IgG1
Application
ELISA, WB, FC

Basic Information

Immunogen
Purified recombinant fragment of human CD248 (aa: extra 18-180) expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
ELISA1:10,000
WB1:500-1:2,000
FC1:200-1:400

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
0.05% sodium azide
Concentration
1 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
CD248 Molecule
Introduction
CD248 (CD248 Molecule) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include calcium ion binding and extracellular matrix binding. An important paralog of this gene is CD93.
Entrez Gene ID
57124
UniProt ID
Q9HCU0
Function
May play a role in tumor angiogenesis.
Biological Process
Anatomical structure regression Source: Ensembl
Cell migration Source: GO_Central
Lymph node development Source: Ensembl
Positive regulation of cell population proliferation Source: Ensembl
Positive regulation of endothelial cell apoptotic process Source: Ensembl
Cellular Location
Membrane
Topology
Extracellular: 18-687
Helical: 688-708
Cytoplasmic: 709-757
PTM
O-glycosylated with sialylated oligosaccharides.
May be N-glycosylated.
More Infomation

Zhang, K., Xu, C., Liu, S., Jiang, Y., Zhao, X., Ma, S., ... & Qin, W. (2021). The Diagnostic and Immunotherapeutic Value of CD248 in Renal Cell Carcinoma. Frontiers in oncology, 11, 510.

Armitage, E. G., Barnes, A., Patrick, K., Bechar, J., Harrison, M. J., Lavery, G. G., ... & Naylor, A. J. (2021). Metabolic consequences for mice lacking Endosialin: LC–MS/MS-based metabolic phenotyping of serum from C56Bl/6J Control and CD248 knock‐out mice. Metabolomics, 17(2), 1-11.

Matsushima, S., Aoshima, Y., Akamatsu, T., Enomoto, Y., Meguro, S., Kosugi, I., ... & Iwashita, T. (2020). CD248 and integrin alpha-8 are candidate markers for differentiating lung fibroblast subtypes. BMC pulmonary medicine, 20(1), 1-15.

Park, G. B., Jeong, J. Y., & Kim, D. (2020). Modified TLR‐mediated downregulation of miR‐125b‐5p enhances CD248 (endosialin)‐induced metastasis and drug resistance in colorectal cancer cells. Molecular carcinogenesis, 59(2), 154-167.

Di Benedetto, P., Ruscitti, P., Liakouli, V., Del Galdo, F., Giacomelli, R., & Cipriani, P. (2019). Linking myofibroblast generation and microvascular alteration: the role of CD248 from pathogenesis to therapeutic target. Molecular medicine reports, 20(2), 1488-1498.

Teicher, B. A. (2019). CD248: A therapeutic target in cancer and fibrotic diseases. Oncotarget, 10(9), 993.

Petrus, P., Fernandez, T. L., Kwon, M. M., Huang, J. L., Lei, V., Safikhan, N. S., ... & Conway, E. M. (2019). Specific loss of adipocyte CD248 improves metabolic health via reduced white adipose tissue hypoxia, fibrosis and inflammation. EBioMedicine, 44, 489-501.

Di Benedetto, P., Liakouli, V., Ruscitti, P., Berardicurti, O., Carubbi, F., Panzera, N., ... & Giacomelli, R. (2018). Blocking CD248 molecules in perivascular stromal cells of patients with systemic sclerosis strongly inhibits their differentiation toward myofibroblasts and proliferation: a new potential target for antifibrotic therapy. Arthritis research & therapy, 20(1), 1-12.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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