Rat Anti-CCR3 Recombinant Antibody (CBYY-C0675) (CBMAB-C1997-YY)

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Datasheet

Summary

Host Animal

Rat

Specificity

Mouse

Clone

CBYY-C0675

Antibody Isotype

IgG2b, λ

Application

In vivo

Basic Information

Immunogen

Y3 cells expressing full length mouse CCR3.

Host Species

Rat

Specificity

Mouse

Antibody Isotype

IgG2b, λ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

None

Concentration

Batch dependent

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

C-C Motif Chemokine Receptor 3

Entrez Gene ID

12771

UniProt ID

P51678

Alternative Names

CD24 Molecule; CD24 Antigen (Small Cell Lung Carcinoma Cluster 4 Antigen); CD24A; Small Cell Lung Carcinoma Cluster 4 Antigen; Signal Transducer CD24; CD24 Antigen;

Function

Receptor for C-C type chemokine. Binds and responds to a variety of chemokines, including CCL11, CCL26, CCL7, CCL13, RANTES(CCL5) and CCL15 (PubMed:7622448, PubMed:8642344, PubMed:8676064).
Subsequently transduces a signal by increasing the intracellular calcium ions level (PubMed:8676064).
In addition acts as a possible functional receptor for NARS1 (PubMed:30171954).
(Microbial infection) Alternative coreceptor with CD4 for HIV-1 infection.

Biological Process

Adenylate cyclase-modulating G protein-coupled receptor signaling pathway Source: ProtInc
Calcium-mediated signaling Source: GO_Central
Cell adhesion Source: ProtInc
Cell chemotaxis Source: GO_Central
Cellular defense response Source: ProtInc
Chemotaxis Source: ProtInc
G protein-coupled receptor signaling pathway Source: Reactome
Immune response Source: GO_Central
Inflammatory response Source: GO_Central
Positive regulation of angiogenesis Source: BHF-UCL
Positive regulation of cytosolic calcium ion concentration Source: GO_Central
Positive regulation of endothelial cell proliferation Source: Ensembl
Viral process Source: UniProtKB-KW

Cellular Location

Cell membrane

Topology

Extracellular: 1-34
Helical: 35-62
Cytoplasmic: 63-72
Helical: 73-93
Extracellular: 94-107
Helical: 108-129
Cytoplasmic: 130-146
Helical: 147-171
Extracellular: 172-203
Helical: 204-223
Cytoplasmic: 224-239
Helical: 240-264
Extracellular: 265-281
Helical: 282-305
Cytoplasmic: 306-355

More Infomation

References

van Aalst, E., Koneri, J., & Wylie, B. J. (2021). In Silico Identification of Cholesterol Binding Motifs in the Chemokine Receptor CCR3. Membranes, 11(8), 570.

Korbecki, J., Kojder, K., Simińska, D., Bohatyrewicz, R., Gutowska, I., Chlubek, D., & Baranowska-Bosiacka, I. (2020). CC chemokines in a tumor: a review of pro-cancer and anti-cancer properties of the ligands of receptors CCR1, CCR2, CCR3, and CCR4. International Journal of Molecular Sciences, 21(21), 8412.

Zhu, X., Liu, K., Wang, J., Peng, H., Pan, Q., Wu, S., ... & Liu, Y. (2018). C‑C chemokine receptor type 3 gene knockout alleviates inflammatory responses in allergic rhinitis model mice by regulating the expression of eosinophil granule proteins and immune factors. Molecular medicine reports, 18(4), 3780-3790.

Turner, J. D., Pionnier, N., Furlong-Silva, J., Sjoberg, H., Cross, S., Halliday, A., ... & Taylor, M. J. (2018). Interleukin-4 activated macrophages mediate immunity to filarial helminth infection by sustaining CCR3-dependent eosinophilia. PLoS pathogens, 14(3), e1006949.

Ge, B., Li, J., Wei, Z., Sun, T., Song, Y., & Khan, N. U. (2017). Functional expression of CCL8 and its interaction with chemokine receptor CCR3. BMC immunology, 18(1), 1-8.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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