Mouse Anti-CALB1 Recombinant Antibody (C1237) (CBMAB-C1237-CN)

See all CALB1 antibodies

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

C1237

Antibody Isotype

IgG

Application

Basic Information

Immunogen

Prokaryotic recombinant protein corresponding to the majority of the calbindin molecule.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Preservative

15 mM Sodium azide

Concentration

Batch dependent

Target

Full Name

Calbindin 1

Introduction

CALB1 (Calbindin 1) is a Protein Coding gene. Diseases associated with CALB1 include Huntington Disease and Temporal Lobe Epilepsy. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Endocrine and other factor-regulated calcium reabsorption. Gene Ontology (GO) annotations related to this gene include calcium ion binding and vitamin D binding. An important paralog of this gene is CALB2.

Entrez Gene ID

793

UniProt ID

P05937

Alternative Names

Calbindin 1; Vitamin D-Dependent Calcium-Binding Protein, Avian-Type; Calbindin 1, 28kDa; Calbindin D28; D-28K; Calbindin 1, (28kD);

Function

Buffers cytosolic calcium. May stimulate a membrane Ca2+-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase.

Biological Process

Amyloid fibril formation Source: Reactome
Cellular response to organic substance Source: Ensembl
Cochlea development Source: Ensembl
Locomotory behavior Source: Ensembl
Long-term memory Source: UniProtKB
Metanephric collecting duct development Source: Ensembl
Metanephric connecting tubule development Source: Ensembl
Metanephric distal convoluted tubule development Source: Ensembl
Metanephric part of ureteric bud development Source: Ensembl
Regulation of cytosolic calcium ion concentration Source: GO_Central
Regulation of long-term synaptic potentiation Source: GO_Central
Regulation of presynaptic cytosolic calcium ion concentration Source: GO_Central
Retina layer formation Source: Ensembl
Short-term memory Source: UniProtKB

Cellular Location

Cuticular plate; Cytosol; Postsynaptic cytosol; Presynaptic cytosol; Extracellular exosome; Nucleus; Axon; Calyx of Held; Dendrite; Dendritic spine; GABA-ergic synapse; Glutamatergic synapse; Hippocampal mossy fiber to CA3 synapse; Neuron projection; Neuronal cell body; Stereocilium; Synapse; Terminal bouton

More Infomation

References

Castrogiovanni, P., Sanfilippo, C., Imbesi, R., Maugeri, G., Lo Furno, D., Tibullo, D., ... & Di Rosa, M. (2021). Brain CHID1 Expression Correlates with NRGN and CALB1 in Healthy Subjects and AD Patients. Cells, 10(4), 882.

of Wang, N., Lavasseur, C. M., Yan, H., Younger, S., Glader, B., Sakamoto, K. M., ... & Narla, A. (2020). Targeting of Calbindin 1 (CALB1) Rescues Erythropoiesis in a Human Model of Diamond Blackfan Anemia: Implications for Novel Therapies. Blood, 136, 4.

Jin, C., Lin, T., & Shan, L. (2019). Downregulation of calbindin 1 by miR-454-3p suppresses cell proliferation in nonsmall cell lung cancer in vitro. Cancer biotherapy & radiopharmaceuticals, 34(2), 119-127.

Cao, L. Q., Wang, Y. N., Liang, M., & Pan, M. Z. (2019). CALB1 enhances the interaction between p53 and MDM2, and inhibits the senescence of ovarian cancer cells. Molecular medicine reports, 19(6), 5097-5104.

Goffigan-Holmes, J., Sanabria, D., Diaz, J., Flock, D., & Chavez-Valdez, R. (2018). Calbindin-1 expression in the hippocampus following neonatal hypoxia-ischemia and therapeutic hypothermia and deficits in spatial memory. Developmental neuroscience, 40(5-6), 508-522.

Huang, Z., Fan, G., & Wang, D. (2017). Downregulation of calbindin 1, a calcium-binding protein, reduces the proliferation of osteosarcoma cells. Oncology letters, 13(5), 3727-3733.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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