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Mouse Anti-CALB1 Recombinant Antibody (CBLC059-LY) (CBMAB-C9630-LY)


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Published Data
CBMAB-C9630-LY-1
Mouse Anti-CALB1 Recombinant Antibody (CBLC059-LY) (CBMAB-C9630-LY) in IF
Double-immunofluorescence staining of CFB (green) and renal intrinsic cells and macrophages (red); bar = 50 μm; magnified insets, original magnification, ×400. ...View More
Sun, Z. J., Chang, D. Y., Chen, M., & Zhao, M. H. (2022). Deficiency of CFB attenuates renal tubulointerstitial damage by inhibiting ceramide synthesis in diabetic kidney disease. JCI insight, 7(24).
CBMAB-C9630-LY-2
Mouse Anti-CALB1 Recombinant Antibody (CBLC059-LY) (CBMAB-C9630-LY) in IHC
IHC analysis of kidney slices was performed to evaluate GPX4 expression levels. In healthy controls, GPX4 was mainly expressed in kidney tubulointerstitium, especially in renal tubular epithelial cells. ...View More
Wang, Y. H., Chang, D. Y., Zhao, M. H., & Chen, M. (2022). Glutathione peroxidase 4 is a predictor of diabetic kidney disease progression in type 2 diabetes mellitus. Oxidative Medicine and Cellular Longevity, 2022(1), 2948248.
CBMAB-C9630-LY-3
Mouse Anti-CALB1 Recombinant Antibody (CBLC059-LY) (CBMAB-C9630-LY) in IF
Co-localization of ANXA1 and Calbindin D28K in renal specimens of AAV patients respectively. ...View More
Wang, R. X., Wu, L., Chen, S. F., Li, Z. Y., Zhao, M. H., & Chen, M. (2022). Renal expression of annexin A1 is associated with the severity of renal injury in antineutrophil cytoplasmic autoantibody-associated vasculitis. Frontiers in Medicine, 9, 769813.
CBMAB-C9630-LY-4
Mouse Anti-CALB1 Recombinant Antibody (CBLC059-LY) (CBMAB-C9630-LY) in IHC
Representative images of GFAP, Glt-1, and Calbindin D28K staining in the grey matter of the cerebellum (total magnification = 100×, scale bar = 50 µm). ...View More
Stelfa, G., Vavers, E., Svalbe, B., Serzants, R., Miteniece, A., Lauberte, L., ... & Zvejniece, L. (2021). Reduced GFAP expression in bergmann glial cells in the cerebellum of sigma-1 receptor knockout mice determines the neurobehavioral outcomes after traumatic brain injury. International Journal of Molecular Sciences, 22(21), 11611.
CBMAB-C9630-LY-5
Mouse Anti-CALB1 Recombinant Antibody (CBLC059-LY) (CBMAB-C9630-LY) in IF
β3-AR localizes to multiple segments of the mouse nephron. Cryosections from wild-type (wt) mouse kidneys were stained with anti-β3-AR (red) and nephron segment-specific markers (green). Calbindin for distal convoluted tubules (DCTs), Na+K+2Cl (NKCC2) co-transporter for the thick ascending limbs (TALs) and Aquaporin 2 (AQP2) for the cortical collecting ducts (CCDs). Confocal microscopic images were acquired at two different magnifications (Upper panels, scale bar = 100 µm; Lower panels, scale bar = 10 µm). Nuclei were stained with Hoechst Nuclear Staining (blue). Positive nephron segments are depicted in the cartoons on the right and colocalization is highlighted in red and green. ...View More
Schena, G., Carmosino, M., Chiurlia, S., Onuchic, L., Mastropasqua, M., Maiorano, E., ... & Caplan, M. J. (2021). β3 adrenergic receptor as potential therapeutic target in ADPKD. Physiological Reports, 9(20), e15058.

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat, Pig, Cattle
Clone
CBLC059-LY
Antibody Isotype
IgG1, κ
Application
E, IF, IP, WB, P

Basic Information

Immunogen
Amino acids 35-84 mapping near the N-terminus of Calbindin D28K of human origin.
Host Species
Mouse
Specificity
Human, Mouse, Rat, Pig, Cattle
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500
ELISA1:100-1:1,000
IHC-P1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
0.09% sodium azide
Concentration
0.2 mg/ml
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Calbindin 1
Introduction
CALB1 (Calbindin 1) is a Protein Coding gene. Diseases associated with CALB1 include Huntington Disease and Temporal Lobe Epilepsy. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Endocrine and other factor-regulated calcium reabsorption. Gene Ontology (GO) annotations related to this gene include calcium ion binding and vitamin D binding. An important paralog of this gene is CALB2.
Entrez Gene ID
Human793
Mouse12307
Rat83839
UniProt ID
HumanP05937
MouseP12658
RatP07171
Function
Buffers cytosolic calcium. May stimulate a membrane Ca2+-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase.
Biological Process
Amyloid fibril formation Source: Reactome
Cellular response to organic substance Source: Ensembl
Cochlea development Source: Ensembl
Locomotory behavior Source: Ensembl
Long-term memory Source: UniProtKB
Metanephric collecting duct development Source: Ensembl
Metanephric connecting tubule development Source: Ensembl
Metanephric distal convoluted tubule development Source: Ensembl
Metanephric part of ureteric bud development Source: Ensembl
Regulation of cytosolic calcium ion concentration Source: GO_Central
Regulation of long-term synaptic potentiation Source: GO_Central
Regulation of presynaptic cytosolic calcium ion concentration Source: GO_Central
Retina layer formation Source: Ensembl
Short-term memory Source: UniProtKB
Cellular Location
Cuticular plate; Cytosol; Postsynaptic cytosol; Presynaptic cytosol; Extracellular exosome; Nucleus; Axon; Calyx of Held; Dendrite; Dendritic spine; GABA-ergic synapse; Glutamatergic synapse; Hippocampal mossy fiber to CA3 synapse; Neuron projection; Neuronal cell body; Stereocilium; Synapse; Terminal bouton
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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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