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Mouse Anti-AOC3 Recombinant Antibody (CBYY-0014) (CBMAB-0014-YY)


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Published Data
Mouse Anti-AOC3 Recombinant Antibody (CBYY-0014) in IF
The co-localization of NF-kB p65 and SSAO. ...View More
Di, Y. L., Yu, Y., Zhao, S. J., Huang, N., Fei, X. C., Yao, D. D., ... & Tong, Z. Q. (2022). Formic acid induces hypertension-related hemorrhage in hSSAOTG in mice and human. Experimental Neurology, 358, 114208.

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBYY-0014
Antibody Isotype
IgG2a, κ
Application
WB, IP, IF, ELISA, IHC-P

Basic Information

Immunogen
Amino acids 749-763 at the C-terminus of VAP-1 of human origin.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500
ELISA1:30-1:3,000
IHC-P1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
< 0.1% sodium azide
Concentration
0.2 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Amine Oxidase, Copper Containing 3
Introduction
This gene encodes a member of the semicarbazide-sensitive amine oxidase family. Copper amine oxidases catalyze the oxidative conversion of amines to aldehydes in the presence of copper and quinone cofactor. The encoded protein is localized to the cell surface, has adhesive properties as well as monoamine oxidase activity, and may be involved in leukocyte trafficking. Alterations in levels of the encoded protein may be associated with many diseases, including diabetes mellitus. A pseudogene of this gene has been described and is located approximately 9-kb downstream on the same chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013]
Entrez Gene ID
8639
UniProt ID
Q16853
Alternative Names
Amine Oxidase, Copper Containing 3; Semicarbazide-Sensitive Amine Oxidase; Vascular Adhesion Protein 1; Copper Amine Oxidase; EC 1.4.3.21; VAP-1; SSAO;
Function
Cell adhesion protein that participates in lymphocyte extravasation and recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin-independent fashion. Has semicarbazide-sensitive (SSAO) monoamine oxidase activity. May play a role in adipogenesis.
Biological Process
Amine metabolic process Source: UniProtKB
Cell adhesion Source: UniProtKB
Inflammatory response Source: UniProtKB
Negative regulation of primary amine oxidase activity Source: UniProtKB
Response to antibiotic Source: UniProtKB
Xenobiotic metabolic process Source: Reactome
Cellular Location
Cell membrane
Topology
Cytoplasmic: 1-5 aa
Helical: 6-26 aa
Extracellular: 27-763 aa
PTM
Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.
N- and O-glycosylated.
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For research use only. Not intended for any clinical use.

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