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Mouse Anti-AOC3 Recombinant Antibody (CBYC-A641) (CBMAB-A2954-YC)


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Published Data
Mouse Anti-AOC3 Recombinant Antibody (CBYC-A641) in IF
Antibody staining of recombinant proteins expressed on the surface of CHO-745 cells. Immunofluorescence analyses (IFA) with non-permeabilized CHO-745 cells confirm surface localization of the overexpressed endothelial proteins. TNFR2sh, HRH1, VAP-1 (green) as well as untagged LOX1 expressed in CHO-745 cells were labelled with respective antibodies (red). No antibodies were available which are directed against any of the nine extracellular domains of MRP2. ...View More
Esser, C., Bachmann, A., Kuhn, D., Schuldt, K., Förster, B., Thiel, M., ... & Horstmann, R. D. (2014). Evidence of promiscuous endothelial binding by P lasmodium falciparum-infected erythrocytes. Cellular microbiology, 16(5), 701-708.
Mouse Anti-AOC3 Recombinant Antibody (CBYC-A641) in WB
Western blot analysis of adipose tissue from 6 wild type VAP-1 (WT) and 6 VAP-1Y471F mice. The upper panel shows the blot probed for VAP-1 and the lower panel shows the same blot which was probed for βTubulin. The VAP-1 and βTubulin bands are indicated with arrows in each case. The molecular weight standard is indicated by Mol. Wt. Stds (kDa) and the 98 and 49 kDa bands are highlighted. ...View More
Noonan, T., Lukas, S., Peet, G. W., Pelletier, J., Panzenbeck, M., Hanidu, A., ... & Modis, L. K. (2013). The oxidase activity of vascular adhesion protein-1 (VAP-1) is essential for function. American journal of clinical and experimental immunology, 2(2), 172.

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYC-A641
Antibody Isotype
IgG2a, κ
Application
WB, IF, FC

Basic Information

Immunogen
Affinity purified VAP-1 from tonsil stroma of human origin.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IF(ICC)1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
< 0.1% sodium azide
Concentration
0.2 mg/ml
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Amine Oxidase, Copper Containing 3
Introduction
AOC3 is a member of the semicarbazide-sensitive amine oxidase family. Copper amine oxidases catalyze the oxidative conversion of amines to aldehydes in the presence of copper and quinone cofactor. The encoded protein is localized to the cell surface, has
Entrez Gene ID
8639
UniProt ID
Q16853
Alternative Names
Amine Oxidase, Copper Containing 3; Semicarbazide-Sensitive Amine Oxidase; Vascular Adhesion Protein 1; Copper Amine Oxidase; EC 1.4.3.21; VAP-1; SSAO;
Function
Cell adhesion protein that participates in lymphocyte extravasation and recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin-independent fashion. Has semicarbazide-sensitive (SSAO) monoamine oxidase activity. May play a role in adipogenesis.
Biological Process
Amine metabolic process Source: UniProtKB
Cell adhesion Source: UniProtKB
Inflammatory response Source: UniProtKB
Negative regulation of primary amine oxidase activity Source: UniProtKB
Response to antibiotic Source: UniProtKB
Xenobiotic metabolic process Source: Reactome
Cellular Location
Cell membrane
Topology
Cytoplasmic: 1-5 aa
Helical: 6-26 aa
Extracellular: 27-763 aa
PTM
Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.
N- and O-glycosylated.
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For research use only. Not intended for any clinical use.

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