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Mouse Anti-AOC3 Recombinant Antibody (4B8) (CBMAB-A2953-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
4B8
Antibody Isotype
IgG2a, κ
Application
ELISA, IF

Basic Information

Immunogen
AOC3 (NP_003725, 351-450 aa) partial recombinant protein with GST tag.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
IF(ICC)10 µg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
None
Concentration
Batch dependent
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 351-450

Target

Full Name
Amine Oxidase, Copper Containing 3
Introduction
AOC3 is a member of the semicarbazide-sensitive amine oxidase family. Copper amine oxidases catalyze the oxidative conversion of amines to aldehydes in the presence of copper and quinone cofactor. The encoded protein is localized to the cell surface, has
Entrez Gene ID
8639
UniProt ID
Q16853
Alternative Names
Amine Oxidase, Copper Containing 3; Semicarbazide-Sensitive Amine Oxidase; Vascular Adhesion Protein 1; Copper Amine Oxidase; EC 1.4.3.21; VAP-1; SSAO;
Function
Cell adhesion protein that participates in lymphocyte extravasation and recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin-independent fashion. Has semicarbazide-sensitive (SSAO) monoamine oxidase activity. May play a role in adipogenesis.
Biological Process
Amine metabolic process Source: UniProtKB
Cell adhesion Source: UniProtKB
Inflammatory response Source: UniProtKB
Negative regulation of primary amine oxidase activity Source: UniProtKB
Response to antibiotic Source: UniProtKB
Xenobiotic metabolic process Source: Reactome
Cellular Location
Cell membrane
Topology
Cytoplasmic: 1-5 aa
Helical: 6-26 aa
Extracellular: 27-763 aa
PTM
Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.
N- and O-glycosylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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