ZWINT

This gene encodes a protein that is clearly involved in kinetochore function although an exact role is not known. It interacts with ZW10, another kinetochore protein, possibly regulating the association between ZW10 and kinetochores. The encoded protein localizes to prophase kinetochores before ZW10 does and it remains detectable on the kinetochore until late anaphase. It has a uniform distribution in the cytoplasm of interphase cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

ZW10 Interacting Kinetochore Protein

Part of the MIS12 complex, which is required for kinetochore formation and spindle checkpoint activity. Required to target ZW10 to the kinetochore at prometaphase.

Biological Process cell division Source:UniProtKB-KW
Biological Process establishment of localization in cell Source:HGNC-UCL1 Publication
Biological Process mitotic sister chromatid segregation Source:HGNC-UCL1 Publication
Biological Process mitotic spindle assembly checkpoint signaling Source:HGNC-UCL1 Publication

Nucleus
Chromosome, centromere, kinetochore
Note: Localizes to kinetochores from late prophase to anaphase.