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Mouse Anti-ZWINT Recombinant Antibody (6D3) (CBMAB-Z0796-WJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
6D3
Antibody Isotype
IgG2a, κ
Application
ELISA, IF, WB

Basic Information

Immunogen
ZWINT (AA1-277) full-length recombinant protein with GST tag.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1 mg/mL

Target

Full Name
ZW10 Interacting Kinetochore Protein
Introduction
This gene encodes a protein that is clearly involved in kinetochore function although an exact role is not known. It interacts with ZW10, another kinetochore protein, possibly regulating the association between ZW10 and kinetochores. The encoded protein localizes to prophase kinetochores before ZW10 does and it remains detectable on the kinetochore until late anaphase. It has a uniform distribution in the cytoplasm of interphase cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Entrez Gene ID
11130
UniProt ID
O95229
Alternative Names
SIP30; ZWINT1; KNTC2AP; HZwint-1
Function
Part of the MIS12 complex, which is required for kinetochore formation and spindle checkpoint activity. Required to target ZW10 to the kinetochore at prometaphase.
Biological Process
Biological Process cell division Source:UniProtKB-KW
Biological Process establishment of localization in cell Source:HGNC-UCL1 Publication
Biological Process mitotic sister chromatid segregation Source:HGNC-UCL1 Publication
Biological Process mitotic spindle assembly checkpoint signaling Source:HGNC-UCL1 Publication
Cellular Location
Nucleus
Chromosome, centromere, kinetochore
Note: Localizes to kinetochores from late prophase to anaphase.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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