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YWHAZ

This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and sheep orthologs. The encoded protein interacts with IRS1 protein, suggesting a role in regulating insulin sensitivity. Several transcript variants that differ in the 5' UTR but that encode the same protein have been identified for this gene. [provided by RefSeq]
Full Name
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
Function
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:14578935, PubMed:15071501, PubMed:15644438, PubMed:16376338, PubMed:16959763, PubMed:31024343, PubMed:9360956).
Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:35662396).
Binding generally results in the modulation of the activity of the binding partner (PubMed:35662396).
Promotes cytosolic retention and inactivation of TFEB transcription factor by binding to phosphorylated TFEB (PubMed:35662396).
Induces ARHGEF7 activity on RAC1 as well as lamellipodia and membrane ruffle formation (PubMed:16959763).
In neurons, regulates spine maturation through the modulation of ARHGEF7 activity (By similarity).
Biological Process
Biological Process angiogenesis Source:Ensembl
Biological Process ERK1 and ERK2 cascade Source:Ensembl
Biological Process establishment of Golgi localization Source:UniProtKB1 Publication
Biological Process Golgi reassembly Source:UniProtKB1 Publication
Biological Process lung development Source:Ensembl
Biological Process negative regulation of apoptotic process Source:ProtInc1 Publication
Biological Process negative regulation of transcription by RNA polymerase II Source:ComplexPortal1 Publication
Biological Process protein localization Source:GO_Central1 Publication
Biological Process protein phosphorylation Source:UniProtKB1 Publication
Biological Process protein targeting Source:Ensembl
Biological Process regulation of ERK1 and ERK2 cascade Source:UniProtKB1 Publication
Biological Process regulation of synapse maturation Source:SynGO2 Publications
Biological Process respiratory system process Source:Ensembl
Biological Process signal transduction Source:UniProtKB1 Publication
Biological Process synaptic target recognition Source:Ensembl
Biological Process tube formation Source:Ensembl
Cellular Location
Cytoplasm
Melanosome
Located to stage I to stage IV melanosomes.
PTM
The delta, brain-specific form differs from the zeta form in being phosphorylated (Probable). Phosphorylation on Ser-184 by MAPK8; promotes dissociation of BAX and translocation of BAX to mitochondria (PubMed:15071501, PubMed:15696159).
Phosphorylation on Thr-232; inhibits binding of RAF1 (PubMed:9360956).
Phosphorylated on Ser-58 by PKA and protein kinase C delta type catalytic subunit in a sphingosine-dependent fashion (PubMed:11956222, PubMed:12865427, PubMed:15883165, PubMed:16376338).
Phosphorylation on Ser-58 by PKA; disrupts homodimerization and heterodimerization with YHAE and TP53 (PubMed:11956222, PubMed:12865427, PubMed:15883165, PubMed:16376338).

Anti-YWHAZ antibodies

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Target: YWHAZ
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse, Rat
Clone: 20
Application*: WB
Target: YWHAZ
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat
Clone: CBLN1-188
Application*: WB
Target: YWHAZ
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Monkey, Mouse, Rat
Clone: 1H9L19
Application*: F, IC, IF, WB
Target: YWHAZ
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: 1B3
Application*: WB, IP, E
Target: YWHAZ
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 818515
Application*: WB, IH
Target: YWHAZ
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYJT-5596
Application*: WB, E
Target: YWHAZ
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 5E8
Application*: WB, E
More Infomation
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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