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Mouse Anti-YWHAZ Recombinant Antibody (2E1) (CBMAB-0996CQ)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
20
Antibody Isotype
IgG2b, κ
Application
WB

Basic Information

Immunogen
Human 14-3-3 zeta aa 1-245
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
Introduction
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
Entrez Gene ID
Human7534
Mouse22631
Rat25578
UniProt ID
HumanP63104
MouseP63101
RatP63102
Alternative Names
HEL4; YWHAD; KCIP-1; HEL-S-3; HEL-S-93; 14-3-3-zeta
Function
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:14578935, PubMed:15071501, PubMed:15644438, PubMed:16376338, PubMed:16959763, PubMed:31024343, PubMed:9360956).
Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:35662396).
Binding generally results in the modulation of the activity of the binding partner (PubMed:35662396).
Promotes cytosolic retention and inactivation of TFEB transcription factor by binding to phosphorylated TFEB (PubMed:35662396).
Induces ARHGEF7 activity on RAC1 as well as lamellipodia and membrane ruffle formation (PubMed:16959763).
In neurons, regulates spine maturation through the modulation of ARHGEF7 activity (By similarity).
Biological Process
Biological Process angiogenesis Source:Ensembl
Biological Process ERK1 and ERK2 cascade Source:Ensembl
Biological Process establishment of Golgi localization Source:UniProtKB1 Publication
Biological Process Golgi reassembly Source:UniProtKB1 Publication
Biological Process lung development Source:Ensembl
Biological Process negative regulation of apoptotic process Source:ProtInc1 Publication
Biological Process negative regulation of transcription by RNA polymerase II Source:ComplexPortal1 Publication
Biological Process protein localization Source:GO_Central1 Publication
Biological Process protein phosphorylation Source:UniProtKB1 Publication
Biological Process protein targeting Source:Ensembl
Biological Process regulation of ERK1 and ERK2 cascade Source:UniProtKB1 Publication
Biological Process regulation of synapse maturation Source:SynGO2 Publications
Biological Process respiratory system process Source:Ensembl
Biological Process signal transduction Source:UniProtKB1 Publication
Biological Process synaptic target recognition Source:Ensembl
Biological Process tube formation Source:Ensembl
Cellular Location
Cytoplasm
Melanosome
Located to stage I to stage IV melanosomes.
PTM
The delta, brain-specific form differs from the zeta form in being phosphorylated (Probable). Phosphorylation on Ser-184 by MAPK8; promotes dissociation of BAX and translocation of BAX to mitochondria (PubMed:15071501, PubMed:15696159).
Phosphorylation on Thr-232; inhibits binding of RAF1 (PubMed:9360956).
Phosphorylated on Ser-58 by PKA and protein kinase C delta type catalytic subunit in a sphingosine-dependent fashion (PubMed:11956222, PubMed:12865427, PubMed:15883165, PubMed:16376338).
Phosphorylation on Ser-58 by PKA; disrupts homodimerization and heterodimerization with YHAE and TP53 (PubMed:11956222, PubMed:12865427, PubMed:15883165, PubMed:16376338).
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For research use only. Not intended for any clinical use.

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