YWHAQ

YWHAQ belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and YWHAQ is 99% identical to the mouse and rat orthologs. This gene is upregulated in patients with amyotrophic lateral sclerosis. YWHAQ contains in its 5' UTR a 6 bp tandem repeat sequence which is polymorphic, however, there is no correlation between the repeat number and the disease.

Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Theta

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1.

Biological Process negative regulation of DNA-templated transcription Source:BHF-UCL1 Publication
Biological Process protein localization Source:GO_Central1 Publication
Biological Process protein targeting Source:Ensembl
Biological Process signal transduction Source:GO_Central1 Publication
Biological Process small GTPase mediated signal transduction Source:Ensembl
Biological Process substantia nigra development Source:UniProtKB1 Publication

Cytoplasm
In neurons, axonally transported to the nerve terminals.

Ser-232 is probably phosphorylated by CK1.