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Mouse Anti-YWHAQ Recombinant Antibody (CBYJT-5595) (CBMAB-T5228-YJ)


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Summary

Host Animal
Mouse
Specificity
Human, Rat
Clone
CBYJT-5595
Antibody Isotype
IgG1
Application
ELISA, WB, IHC, IF, FC

Basic Information

Specificity
Human, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Theta
Introduction
YWHAQ belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and YWHAQ is 99% identical to the mouse and rat orthologs. This gene is upregulated in patients with amyotrophic lateral sclerosis. YWHAQ contains in its 5' UTR a 6 bp tandem repeat sequence which is polymorphic, however, there is no correlation between the repeat number and the disease.
Entrez Gene ID
Human10971
Rat25577
UniProt ID
HumanP27348
RatP68255
Alternative Names
Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein Theta; Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein, Theta Polypeptide; 14-3-3 Protein T-Cell; 14-3-3 Protein Tau; Protein, Theta; 14-3-3 Protein Theta
Function
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negatively regulates the kinase activity of PDPK1.
Biological Process
Biological Process negative regulation of DNA-templated transcription Source:BHF-UCL1 Publication
Biological Process protein localization Source:GO_Central1 Publication
Biological Process protein targeting Source:Ensembl
Biological Process signal transduction Source:GO_Central1 Publication
Biological Process small GTPase mediated signal transduction Source:Ensembl
Biological Process substantia nigra development Source:UniProtKB1 Publication
Cellular Location
Cytoplasm
In neurons, axonally transported to the nerve terminals.
PTM
Ser-232 is probably phosphorylated by CK1.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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