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XRCC1

The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity.
Full Name
XRCC1
Function
Scaffold protein involved in DNA single-strand break repair by mediating the assembly of DNA break repair protein complexes (PubMed:11163244, PubMed:28002403).
Negatively regulates ADP-ribosyltransferase activity of PARP1 during base-excision repair in order to prevent excessive PARP1 activity (PubMed:34102106, PubMed:34811483, PubMed:28002403).
Recognizes and binds poly-ADP-ribose chains: specifically binds auto-poly-ADP-ribosylated PARP1, limiting its activity (PubMed:14500814, PubMed:34102106, PubMed:34811483).
Biological Process
Biological Process base-excision repair Source:UniProtKB2 Publications
Biological Process cerebellum morphogenesis Source:Ensembl
Biological Process double-strand break repair via nonhomologous end joining Source:Ensembl
Biological Process hippocampus development Source:Ensembl
Biological Process negative regulation of protection from non-homologous end joining at telomere Source:Ensembl
Biological Process negative regulation of protein ADP-ribosylation Source:UniProtKB2 Publications
Biological Process positive regulation of DNA ligase activity Source:UniProtKB1 Publication
Biological Process positive regulation of single strand break repair Source:UniProtKB1 Publication
Biological Process replication-born double-strand break repair via sister chromatid exchange Source:UniProtKB1 Publication
Biological Process response to hydroperoxide Source:UniProtKB1 Publication
Biological Process response to hypoxia Source:Ensembl
Biological Process response to organic substance Source:Ensembl
Biological Process response to xenobiotic stimulus Source:Ensembl
Biological Process single strand break repair Source:InterPro
Biological Process telomeric DNA-containing double minutes formation Source:Ensembl
Biological Process voluntary musculoskeletal movement Source:UniProtKB1 Publication
Cellular Location
Nucleus
Chromosome
Moves from the nucleoli to the global nuclear chromatin upon DNA damage (PubMed:28002403).
Recruited to DNA damage sites fowwing interaction with poly-ADP-ribose chains (PubMed:14500814).
Involvement in disease
Spinocerebellar ataxia, autosomal recessive, 26 (SCAR26):
A form of spinocerebellar ataxia, a clinically and genetically heterogeneous group of cerebellar disorders due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCAR26 is a progressive disease characterized by gait and limb ataxia, loss of independent ambulation, oculomotor apraxia, and peripheral neuropathy with distal muscle weakness and areflexia.
PTM
Phosphorylation of Ser-371 causes dimer dissociation. Phosphorylation by CK2 promotes interaction with APTX and APLF.
Sumoylated.

Anti-XRCC1 antibodies

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Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)
Target: XRCC1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 3H56
Application*: IP, WB
Target: XRCC1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 3F399
Application*: IH, IP, WB
Target: XRCC1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Rat
Clone: 3F400
Application*: IH, IP, WB
Target: XRCC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey
Clone: UMAB40
Application*: IH, IF
Target: XRCC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2G8
Application*: WB, F
Target: XRCC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3F6-G7-F7
Application*: WB
Target: XRCC1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYCX-127
Application*: WB
Target: XRCC1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 144
Application*: P, WB
Target: XRCC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2D8
Application*: F, IH, P, WB
Target: XRCC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2F8
Application*: ICC, IF, IH, P, WB
Target: XRCC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2E8
Application*: ICC, IF, WB
Target: XRCC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3C3
Application*: ICC, IF, WB
Target: XRCC1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Rat
Clone: 33-2-5
Application*: ICC, IF, C, P, IP, WB
Target: XRCC1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2H4
Application*: E, IF, WB
Target: XRCC1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2H8
Application*: WB
Target: XRCC1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse
Clone: SPM327
Application*: P
Target: XRCC1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 20G3
Application*: E, M
More Infomation
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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