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Mouse Anti-XRCC1 Recombinant Antibody (3F6-G7-F7) (CBMAB-X0180-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
3F6-G7-F7
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Purified recombinant human XRCC1 protein fragments expressed in E.coli
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
XRCC1
Introduction
XRCC1 is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. XRCC1 interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in XRCC1 is associated with cancer in patients of varying radiosensitivity.
Entrez Gene ID
7515
UniProt ID
P18887
Alternative Names
RCC; SCAR26
Function
Scaffold protein involved in DNA single-strand break repair by mediating the assembly of DNA break repair protein complexes (PubMed:11163244, PubMed:28002403).
Negatively regulates ADP-ribosyltransferase activity of PARP1 during base-excision repair in order to prevent excessive PARP1 activity (PubMed:34102106, PubMed:34811483, PubMed:28002403).
Recognizes and binds poly-ADP-ribose chains: specifically binds auto-poly-ADP-ribosylated PARP1, limiting its activity (PubMed:14500814, PubMed:34102106, PubMed:34811483).
Biological Process
Biological Process base-excision repair Source:UniProtKB2 Publications
Biological Process cerebellum morphogenesis Source:Ensembl
Biological Process double-strand break repair via nonhomologous end joining Source:Ensembl
Biological Process hippocampus development Source:Ensembl
Biological Process negative regulation of protection from non-homologous end joining at telomere Source:Ensembl
Biological Process negative regulation of protein ADP-ribosylation Source:UniProtKB2 Publications
Biological Process positive regulation of DNA ligase activity Source:UniProtKB1 Publication
Biological Process positive regulation of single strand break repair Source:UniProtKB1 Publication
Biological Process replication-born double-strand break repair via sister chromatid exchange Source:UniProtKB1 Publication
Biological Process response to hydroperoxide Source:UniProtKB1 Publication
Biological Process response to hypoxia Source:Ensembl
Biological Process response to organic substance Source:Ensembl
Biological Process response to xenobiotic stimulus Source:Ensembl
Biological Process single strand break repair Source:InterPro
Biological Process telomeric DNA-containing double minutes formation Source:Ensembl
Biological Process voluntary musculoskeletal movement Source:UniProtKB1 Publication
Cellular Location
Nucleus
Chromosome
Moves from the nucleoli to the global nuclear chromatin upon DNA damage (PubMed:28002403).
Recruited to DNA damage sites fowwing interaction with poly-ADP-ribose chains (PubMed:14500814).
Involvement in disease
Spinocerebellar ataxia, autosomal recessive, 26 (SCAR26):
A form of spinocerebellar ataxia, a clinically and genetically heterogeneous group of cerebellar disorders due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCAR26 is a progressive disease characterized by gait and limb ataxia, loss of independent ambulation, oculomotor apraxia, and peripheral neuropathy with distal muscle weakness and areflexia.
PTM
Phosphorylation of Ser-371 causes dimer dissociation. Phosphorylation by CK2 promotes interaction with APTX and APLF.
Sumoylated.
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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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