VSIR

VSIR (V-Set Immunoregulatory Receptor) is a Protein Coding gene. Diseases associated with VSIR include Parasagittal Meningioma and Solar Retinopathy. Among its related pathways are T Cell Co-Signaling Pathway: Ligand-Receptor Interactions and NF-kappaB Signaling.

V-set immunoregulatory receptor

Immunoregulatory receptor which inhibits the T-cell response (PubMed:24691993).
May promote differentiation of embryonic stem cells, by inhibiting BMP4 signaling (By similarity).
May stimulate MMP14-mediated MMP2 activation (PubMed:20666777).

Biological Process negative regulation of alpha-beta T cell activation Source:GO_Central1 Publication
Biological Process negative regulation of CD4-positive, alpha-beta T cell proliferation Source:UniProtKB1 Publication
Biological Process negative regulation of CD8-positive, alpha-beta T cell proliferation Source:UniProtKB1 Publication
Biological Process negative regulation of interleukin-10 production Source:UniProtKB1 Publication
Biological Process negative regulation of interleukin-17 production Source:UniProtKB1 Publication
Biological Process negative regulation of tumor necrosis factor production Source:UniProtKB1 Publication
Biological Process negative regulation of type II interferon production Source:UniProtKB1 Publication
Biological Process positive regulation of cell migration Source:UniProtKB1 Publication
Biological Process positive regulation of collagen catabolic process Source:UniProtKB1 Publication
Biological Process positive regulation of endopeptidase activity Source:UniProtKB1 Publication
Biological Process positive regulation of gene expression Source:UniProtKB1 Publication
Biological Process positive regulation of regulatory T cell differentiation Source:UniProtKB1 Publication
Biological Process regulation of immune response Source:InterPro
Biological Process zymogen activation Source:UniProtKB1 Publication

Cell membrane

Extracellular: 33-194
Helical: 195-215
Cytoplasmic: 216-311

At the cell surface, may be cleaved by MMP14.
N-glycosylated.