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Mouse Anti-VSIR Recombinant Antibody (CBWJC-4580) (CBMAB-C5984WJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBWJC-4580
Antibody Isotype
IgG1
Application
IHC

Basic Information

Immunogen
Recombinant Human C10orf54
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 40% glycerol, pH 7.2
Preservative
0.02% sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
V-set immunoregulatory receptor
Introduction
VSIR (V-Set Immunoregulatory Receptor) is a Protein Coding gene. Diseases associated with VSIR include Parasagittal Meningioma and Solar Retinopathy. Among its related pathways are T Cell Co-Signaling Pathway: Ligand-Receptor Interactions and NF-kappaB Signaling.
Entrez Gene ID
64115
UniProt ID
Q9H7M9
Alternative Names
V-Set Immunoregulatory Receptor; V-Set Domain-Containing Immunoregulatory Receptor; V-Domain Ig Suppressor Of T Cell Activation; Stress-Induced Secreted Protein-1; PDCD1 Homolog; C10orf54; Sisp-1; SISP1; VISTA; V-Type Immunoglobulin Domain-Containing Suppressor Of T-Cell Activation; Chromosome 10 Open Reading Frame 54;
Function
Immunoregulatory receptor which inhibits the T-cell response (PubMed:24691993).
May promote differentiation of embryonic stem cells, by inhibiting BMP4 signaling (By similarity).
May stimulate MMP14-mediated MMP2 activation (PubMed:20666777).
Biological Process
Biological Process negative regulation of alpha-beta T cell activation Source:GO_Central1 Publication
Biological Process negative regulation of CD4-positive, alpha-beta T cell proliferation Source:UniProtKB1 Publication
Biological Process negative regulation of CD8-positive, alpha-beta T cell proliferation Source:UniProtKB1 Publication
Biological Process negative regulation of interleukin-10 production Source:UniProtKB1 Publication
Biological Process negative regulation of interleukin-17 production Source:UniProtKB1 Publication
Biological Process negative regulation of tumor necrosis factor production Source:UniProtKB1 Publication
Biological Process negative regulation of type II interferon production Source:UniProtKB1 Publication
Biological Process positive regulation of cell migration Source:UniProtKB1 Publication
Biological Process positive regulation of collagen catabolic process Source:UniProtKB1 Publication
Biological Process positive regulation of endopeptidase activity Source:UniProtKB1 Publication
Biological Process positive regulation of gene expression Source:UniProtKB1 Publication
Biological Process positive regulation of regulatory T cell differentiation Source:UniProtKB1 Publication
Biological Process regulation of immune response Source:InterPro
Biological Process zymogen activation Source:UniProtKB1 Publication
Cellular Location
Cell membrane
Topology
Extracellular: 33-194
Helical: 195-215
Cytoplasmic: 216-311
PTM
At the cell surface, may be cleaved by MMP14.
N-glycosylated.
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For research use only. Not intended for any clinical use.

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