VAV1

This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The encoded protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. The encoded protein has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

VAV1

Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation.

Biological Process cell migration Source:GO_Central1 Publication
Biological Process cellular response to xenobiotic stimulus Source:Reactome
Biological Process Fc-epsilon receptor signaling pathway Source:Reactome
Biological Process Fc-gamma receptor signaling pathway involved in phagocytosis Source:Reactome
Biological Process G protein-coupled receptor signaling pathway Source:Ensembl
Biological Process immune response Source:Ensembl
Biological Process integrin-mediated signaling pathway Source:Ensembl
Biological Process neutrophil chemotaxis Source:Ensembl
Biological Process platelet activation Source:Reactome
Biological Process positive regulation of GTPase activity Source:Ensembl
Biological Process positive regulation of natural killer cell mediated cytotoxicity Source:Ensembl
Biological Process reactive oxygen species metabolic process Source:Ensembl
Biological Process regulation of cell size Source:UniProtKB1 Publication
Biological Process regulation of GTPase activity Source:UniProtKB1 Publication
Biological Process regulation of small GTPase mediated signal transduction Source:Reactome
Biological Process small GTPase mediated signal transduction Source:InterPro
Biological Process T cell costimulation Source:Reactome
Biological Process T cell differentiation Source:Ensembl
Biological Process vascular endothelial growth factor receptor signaling pathway Source:Reactome

cell-cell junction
cytoplasm
cytosol
plasma membrane

Phosphorylated on tyrosine residues by HCK in response to IFNG and bacterial lipopolysaccharide (LPS) (By similarity).
Phosphorylated by FYN.