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Mouse Anti-VAV1 Antibody (1F4) (CBMAB-1799CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
1F4
Antibody Isotype
IgG
Application
ELISA, MA

Basic Information

Immunogen
Recombinant protein (aa 660-793; SH2 domain)
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
VAV1
Introduction
This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. The protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. Diseases associated with VAV1 include Spherocytosis, Type 1 and Common Variable Immunodeficiency. Among its related pathways are p75 NTR receptor-mediated signalling and RET signaling.
Entrez Gene ID
7409
UniProt ID
P15498
Alternative Names
VAV; vav guanine nucleotide exchange factor 1
Function
Couples tyrosine kinase signals with the activation of the Rho/Rac GTPases, thus leading to cell differentiation and/or proliferation.
Biological Process
Biological Process cell migration Source:GO_Central1 Publication
Biological Process cellular response to xenobiotic stimulus Source:Reactome
Biological Process Fc-epsilon receptor signaling pathway Source:Reactome
Biological Process Fc-gamma receptor signaling pathway involved in phagocytosis Source:Reactome
Biological Process G protein-coupled receptor signaling pathway Source:Ensembl
Biological Process immune response Source:Ensembl
Biological Process integrin-mediated signaling pathway Source:Ensembl
Biological Process neutrophil chemotaxis Source:Ensembl
Biological Process platelet activation Source:Reactome
Biological Process positive regulation of GTPase activity Source:Ensembl
Biological Process positive regulation of natural killer cell mediated cytotoxicity Source:Ensembl
Biological Process reactive oxygen species metabolic process Source:Ensembl
Biological Process regulation of cell size Source:UniProtKB1 Publication
Biological Process regulation of GTPase activity Source:UniProtKB1 Publication
Biological Process regulation of small GTPase mediated signal transduction Source:Reactome
Biological Process small GTPase mediated signal transduction Source:InterPro
Biological Process T cell costimulation Source:Reactome
Biological Process T cell differentiation Source:Ensembl
Biological Process vascular endothelial growth factor receptor signaling pathway Source:Reactome
Cellular Location
cell-cell junction
cytoplasm
cytosol
plasma membrane
PTM
Phosphorylated on tyrosine residues by HCK in response to IFNG and bacterial lipopolysaccharide (LPS) (By similarity).
Phosphorylated by FYN.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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