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UTRN

This gene shares both structural and functional similarities with the dystrophin gene. It contains an actin-binding N-terminus, a triple coiled-coil repeat central region, and a C-terminus that consists of protein-protein interaction motifs which interact with dystroglycan protein components. The protein encoded by this gene is located at the neuromuscular synapse and myotendinous junctions, where it participates in post-synaptic membrane maintenance and acetylcholine receptor clustering. Mouse studies suggest that this gene may serve as a functional substitute for the dystrophin gene and therefore, may serve as a potential therapeutic alternative to muscular dystrophy which is caused by mutations in the dystrophin gene. Alternative splicing of the utrophin gene has been described; however, the full-length nature of these variants has not yet been determined. [provided by RefSeq]

Full Name

utrophin

Function

May play a role in anchoring the cytoskeleton to the plasma membrane.

Biological Process

Biological Process actin cytoskeleton organization Source:GO_Central1 Publication
Biological Process muscle contraction Source:ProtInc1 Publication
Biological Process muscle organ development Source:ProtInc1 Publication
Biological Process positive regulation of cell-matrix adhesion Source:UniProtKB1 Publication
Biological Process regulation of sodium ion transmembrane transporter activity Source:BHF-UCLBy Similarity

Cellular Location

Postsynaptic cell membrane
Cytoplasm, cytoskeleton
Neuromuscular junction.

Anti-UTRN antibodies

Mouse Anti-UTRN (aa 768-874) Recombinant Antibody (CBXU-007) (CBMAB-U0124-CQ)

SDS

Target: UTRN

Host: Mouse

Antibody Isotype: IgG1

Specificity: Mouse

Clone: CBXU-007

Application*: WB

Mouse Anti-UTRN Antibody (9E10) (CBMAB-1771CQ)

SDS

Target: UTRN

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 9E10

Application*: WB, IF

Mouse Anti-UTRN Antibody (9F2) (CBMAB-1772CQ)

SDS

Target: UTRN

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Fish, Mouse

Clone: 9F2

Application*: IF, WB

Mouse Anti-UTRN Antibody (2G12) (CBMAB-1773CQ)

SDS

Target: UTRN

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 2G12

Application*: IF, WB

Mouse Anti-UTRN Antibody (40) (CBMAB-1774CQ)

SDS

Target: UTRN

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 40

Application*: IF, WB

Mouse Anti-UTRN Antibody (4C8) (CBMAB-1775CQ)

SDS

Target: UTRN

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human, Common fruit fly, Fish, Mouse

Clone: 4C8

Application*: IF, WB

Mouse Anti-UTRN Antibody (3C1) (CBMAB-1776CQ)

SDS

Target: UTRN

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human, Fish, Mouse, Frog

Clone: 3C1

Application*: IF, WB

Mouse Anti-UTRN Antibody (9G3) (CBMAB-1777CQ)

SDS

Target: UTRN

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Dog, Mouse, Frog

Clone: 9G3

Application*: WB, IF

Mouse Anti-UTRN Antibody (8A4) (CBMAB-1778CQ)

SDS

Target: UTRN

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Dog, Mouse, Frog

Clone: 8A4

Application*: IF, IH, WB

Mouse Anti-UTRN Antibody (2G5) (CBMAB-1779CQ)

SDS

Target: UTRN

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Dog, Mouse, Frog

Clone: 2G5

Application*: IF, IH, WB

Mouse Anti-UTRN Antibody (7F3) (CBMAB-1780CQ)

SDS

Target: UTRN

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human, Mouse

Clone: 7F3

Application*: IF, IH, WB

Mouse Anti-UTRN Antibody (3B6) (CBMAB-1781CQ)

SDS

Target: UTRN

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 3B6

Application*: WB, IF

Mouse Anti-UTRN Antibody (3B3) (CBMAB-1782CQ)

SDS

Target: UTRN

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 3B3

Application*: WB

Mouse Anti-UTRN Antibody (4B12) (CBMAB-1783CQ)

SDS

Target: UTRN

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 4B12

Application*: WB

Mouse Anti-UTRN Antibody (2A5) (CBMAB-1784CQ)

SDS

Target: UTRN

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 2A5

Application*: WB

Mouse Anti-UTRN Antibody (8A3) (CBMAB-1785CQ)

SDS

Target: UTRN

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 8A3

Application*: WB

Mouse Anti-UTRN Antibody (5E10) (CBMAB-1786CQ)

SDS

Target: UTRN

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 5E10

Application*: WB

Mouse Anti-UTRN Antibody (5C9) (CBMAB-1787CQ)

SDS

Target: UTRN

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 5C9

Application*: WB

Mouse Anti-UTRN Antibody (4E3) (CBMAB-1788CQ)

SDS

Target: UTRN

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 4E3

Application*: WB

Mouse Anti-UTRN Antibody (6H4) (CBMAB-1789CQ)

SDS

Target: UTRN

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 6H4

Application*: WB

Mouse Anti-UTRN Antibody (8C11) (CBMAB-1790CQ)

SDS

Target: UTRN

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 8C11

Application*: WB

Mouse Anti-UTRN Antibody (10D4) (CBMAB-1791CQ)

SDS

Target: UTRN

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 10D4

Application*: WB

Mouse Anti-UTRN Antibody (6A10) (CBMAB-1792CQ)

SDS

Target: UTRN

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 6A10

Application*: WB

Mouse Anti-UTRN Antibody (10A7) (CBMAB-1793CQ)

SDS

Target: UTRN

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 10A7

Application*: WB

Mouse Anti-UTRN Antibody (7C11) (CBMAB-1794CQ)

SDS

Target: UTRN

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 7C11

Application*: WB

Mouse Anti-UTRN Recombinant Antibody (5G6) (CBMAB-U0101-CQ)

SDS

Target: UTRN

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 5G6

Application*: E, IF, WB

More Infomation

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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