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Mouse Anti-UTRN (aa 768-874) Recombinant Antibody (CBXU-007) (CBMAB-U0124-CQ)


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Summary

Host Animal
Mouse
Specificity
Mouse
Clone
CBXU-007
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Mouse Utrophin aa. 768-874
Specificity
Mouse
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
0.25 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 768-874

Target

Full Name
utrophin
Introduction
This gene shares both structural and functional similarities with the dystrophin gene. It contains an actin-binding N-terminus, a triple coiled-coil repeat central region, and a C-terminus that consists of protein-protein interaction motifs which interact with dystroglycan protein components. The protein encoded by this gene is located at the neuromuscular synapse and myotendinous junctions, where it participates in post-synaptic membrane maintenance and acetylcholine receptor clustering. Diseases associated with UTRN include Muscular Dystrophy, Becker Type and Muscular Dystrophy, Duchenne Type. Among its related pathways are Primary Focal Segmental Glomerulosclerosis FSGS and Agrin Interactions at Neuromuscular Junction.
Entrez Gene ID
22288
UniProt ID
E9Q6R7
Alternative Names
UTRN; utrophin; DMDL, utrophin (homologous to dystrophin); DRP; DRP1; DRP-1; dystrophin-related protein 1; DMDL; FLJ23678
Function
May play a role in anchoring the cytoskeleton to the plasma membrane.
Biological Process
Biological Process actin cytoskeleton organization Source:GO_Central1 Publication
Biological Process muscle contraction Source:ProtInc1 Publication
Biological Process muscle organ development Source:ProtInc1 Publication
Biological Process positive regulation of cell-matrix adhesion Source:UniProtKB1 Publication
Biological Process regulation of sodium ion transmembrane transporter activity Source:BHF-UCLBy Similarity
Cellular Location
Postsynaptic cell membrane
Cytoplasm, cytoskeleton
Neuromuscular junction.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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