USP22

Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation and cell cycle progression.

ubiquitin specific peptidase 22

Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation and cell cycle progression.

Biological Process cell cycle Source:UniProtKB-KW
Biological Process chromatin organization Source:UniProtKB-KW
Biological Process embryo development ending in birth or egg hatching Source:UniProtKB1 Publication
Biological Process histone deubiquitination Source:UniProtKB2 Publications
Biological Process histone H3 acetylation Source:ComplexPortal1 Publication
Biological Process histone ubiquitination Source:UniProtKB1 Publication
Biological Process monoubiquitinated histone deubiquitination Source:ComplexPortal1 Publication
Biological Process monoubiquitinated histone H2A deubiquitination Source:ComplexPortal1 Publication
Biological Process positive regulation of DNA-templated transcription Source:UniProtKB1 Publication
Biological Process positive regulation of mitotic cell cycle Source:UniProtKB1 Publication
Biological Process protein deubiquitination Source:UniProtKB1 Publication
Biological Process regulation of DNA repair Source:ComplexPortal2 Publications
Biological Process regulation of RNA splicing Source:ComplexPortal1 Publication
Biological Process regulation of transcription by RNA polymerase II Source:ComplexPortal1 Publication
Biological Process ubiquitin-dependent protein catabolic process Source:InterPro

Nucleus