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Mouse Anti-USP22 Recombinant Antibody (CBXU-088) (CBMAB-U0189-CQ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXU-088
Antibody Isotype
IgG
Application
WB, IF, IP

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
ubiquitin specific peptidase 22
Introduction
Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator.
Entrez Gene ID
23326
UniProt ID
Q9UPT9
Alternative Names
USP3L
Function
Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation and cell cycle progression.
Biological Process
Biological Process cell cycle Source:UniProtKB-KW
Biological Process chromatin organization Source:UniProtKB-KW
Biological Process embryo development ending in birth or egg hatching Source:UniProtKB1 Publication
Biological Process histone deubiquitination Source:UniProtKB2 Publications
Biological Process histone H3 acetylation Source:ComplexPortal1 Publication
Biological Process histone ubiquitination Source:UniProtKB1 Publication
Biological Process monoubiquitinated histone deubiquitination Source:ComplexPortal1 Publication
Biological Process monoubiquitinated histone H2A deubiquitination Source:ComplexPortal1 Publication
Biological Process positive regulation of DNA-templated transcription Source:UniProtKB1 Publication
Biological Process positive regulation of mitotic cell cycle Source:UniProtKB1 Publication
Biological Process protein deubiquitination Source:UniProtKB1 Publication
Biological Process regulation of DNA repair Source:ComplexPortal2 Publications
Biological Process regulation of RNA splicing Source:ComplexPortal1 Publication
Biological Process regulation of transcription by RNA polymerase II Source:ComplexPortal1 Publication
Biological Process ubiquitin-dependent protein catabolic process Source:InterPro
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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