UCKL1

The protein encoded by this gene is a uridine kinase. Uridine kinases catalyze the phosphorylation of uridine to uridine monophosphate. This protein has been shown to bind to Epstein-Barr nuclear antigen 3 as well as natural killer lytic-associated molecule. Ubiquitination of this protein is enhanced by the presence of natural killer lytic-associated molecule. In addition, protein levels decrease in the presence of natural killer lytic-associated molecule, suggesting that association with natural killer lytic-associated molecule results in ubiquitination and subsequent degradation of this protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]

uridine-cytidine kinase 1-like 1

May contribute to UTP accumulation needed for blast transformation and proliferation.

Biological Process CTP salvage Source:UniProtKB-UniPathway
Biological Process phosphorylation Source:UniProtKB-KW
Biological Process pyrimidine nucleoside salvage Source:Reactome
Biological Process UMP salvage Source:UniProtKB-UniPathway

Cytoplasm
Nucleus
EBNA3 induces isoform 1 translocation to the nucleus, whereas it does change isoform 3 location.

Ubiquitinated by RNF19B; which induces proteasomal degradation.