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TYK2

This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq, Jul 2008]
Full Name
TYK2 Gene(Protein Coding) Tyrosine Kinase 2
Function
Non-receptor kinase involved in various processes including cell growth, development, cell migration, innate and adaptive immunity (PubMed:10995743, PubMed:10542297).
Plays both structural and catalytic roles in numerous cytokines and interferons signaling (PubMed:10542297).
Associates with cytokine and growth factor receptors and activate STAT family members including STAT1, STAT3, STAT4 or STAT6 (PubMed:10542297, PubMed:7638186).
The heterodimeric cytokine receptor complexes are composed of a TYK2-associated receptor chain (IFNAR1, IL12RB1, IL10RB or IL13RA1) which serves as the signal transducing chain harboring STAT docking sites once phosphorylated by TYK2, and a second receptor chain associated either with JAK1 or JAK2 (PubMed:10542297, PubMed:7526154, PubMed:25762719).
In turn, recruited STATs are phosphorylated, form homo- and heterodimers, translocate to the nucleus, and regulate cytokine/growth factor responsive genes. Negatively regulates STAT3 activity by promototing phosphorylation at a specific tyrosine that differs from the site used for signaling (PubMed:29162862).
Biological Process
Cellular response to virus1 PublicationIC:ComplexPortal
Cytokine-mediated signaling pathwayTAS:Reactome
Immune response1 PublicationIC:ComplexPortal
Intracellular signal transductionIEA:InterPro
Positive regulation of interferon-gamma productionManual Assertion Based On ExperimentIDA:ComplexPortal
Positive regulation of interleukin-17 production1 PublicationIC:ComplexPortal
Positive regulation of natural killer cell proliferationManual Assertion Based On ExperimentIDA:ComplexPortal
Positive regulation of NK T cell proliferationManual Assertion Based On ExperimentIDA:ComplexPortal
Positive regulation of receptor signaling pathway via JAK-STATManual Assertion Based On ExperimentIDA:ComplexPortal
Positive regulation of T cell proliferationManual Assertion Based On ExperimentIDA:ComplexPortal
Positive regulation of T-helper 17 type immune response1 PublicationIC:ComplexPortal
Protein phosphorylationManual Assertion Based On ExperimentTAS:ProtInc
Type I interferon signaling pathwayTAS:Reactome
Type III interferon signaling pathway1 PublicationIC:ComplexPortal
Cellular Location
cytoplasm
cytoskeleton
cytosol
extracellular exosome
interleukin-12 receptor complex
interleukin-23 receptor complex
nucleus
plasma membrane
Involvement in disease
Immunodeficiency 35 (IMD35):
A primary immunodeficiency characterized by recurrent skin abscesses, pneumonia, and highly elevated serum IgE.
PTM
Phosphorylated (PubMed:7638186).
Phosphorylations at Tyr-1054 and Tyr-1055 induce kinase activation (PubMed:8702790).

Anti-TYK2 antibodies

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Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)
Target: TYK2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 8G8E9,8G9H5,8G8B3
Application*: WB
Target: TYK2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-5501
Application*: E, WB
Target: TYK2
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human
Clone: CBYJT-5502
Application*: WB
Target: TYK2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYJT-5503
Application*: E, IF, IH, IP, WB
Target: TYK2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYJT-5504
Application*: E, WB
Target: TYK2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-5505
Application*: E, WB
Target: TYK2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Monkey
Clone: CBYJT-5506
Application*: WB, IP
Target: TYK2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 5A4
Application*: WB, E
Target: TYK2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 6G12
Application*: WB, E
Target: TYK2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 6H1
Application*: WB, E
Target: TYK2
Host: Mouse
Specificity: Human
Clone: CBWJT-019
Application*: WB, IC, P, IH-F, E
More Infomation
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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