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Rabbit Anti-TYK2 Recombinant Antibody (CBYJT-5506) (CBMAB-T5122-YJ)


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Summary

Host Animal
Rabbit
Specificity
Human, Monkey
Clone
CBYJT-5506
Antibody Isotype
IgG
Application
WB, IP

Basic Information

Specificity
Human, Monkey
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
TYK2 Gene(Protein Coding) Tyrosine Kinase 2
Introduction
TYK2 is a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. TYK2 associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. TYK2 is also component of both the type I and type III interferon signaling pathways. As such, TYK2 may function in anti-viral immunity. A mutation in TYK2 has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E.
Entrez Gene ID
Human7297
Monkey574130
UniProt ID
HumanP29597
MonkeyF7DRD4
Alternative Names
Tyrosine Kinase 2; EC 2.7.10.2; Non-Receptor Tyrosine-Protein Kinase TYK2; EC 2.7.10; IMD35; JTK1
Function
Non-receptor kinase involved in various processes including cell growth, development, cell migration, innate and adaptive immunity (PubMed:10995743, PubMed:10542297).
Plays both structural and catalytic roles in numerous cytokines and interferons signaling (PubMed:10542297).
Associates with cytokine and growth factor receptors and activate STAT family members including STAT1, STAT3, STAT4 or STAT6 (PubMed:10542297, PubMed:7638186).
The heterodimeric cytokine receptor complexes are composed of a TYK2-associated receptor chain (IFNAR1, IL12RB1, IL10RB or IL13RA1) which serves as the signal transducing chain harboring STAT docking sites once phosphorylated by TYK2, and a second receptor chain associated either with JAK1 or JAK2 (PubMed:10542297, PubMed:7526154, PubMed:25762719).
In turn, recruited STATs are phosphorylated, form homo- and heterodimers, translocate to the nucleus, and regulate cytokine/growth factor responsive genes. Negatively regulates STAT3 activity by promototing phosphorylation at a specific tyrosine that differs from the site used for signaling (PubMed:29162862).
Biological Process
Cellular response to virus1 PublicationIC:ComplexPortal
Cytokine-mediated signaling pathwayTAS:Reactome
Immune response1 PublicationIC:ComplexPortal
Intracellular signal transductionIEA:InterPro
Positive regulation of interferon-gamma productionManual Assertion Based On ExperimentIDA:ComplexPortal
Positive regulation of interleukin-17 production1 PublicationIC:ComplexPortal
Positive regulation of natural killer cell proliferationManual Assertion Based On ExperimentIDA:ComplexPortal
Positive regulation of NK T cell proliferationManual Assertion Based On ExperimentIDA:ComplexPortal
Positive regulation of receptor signaling pathway via JAK-STATManual Assertion Based On ExperimentIDA:ComplexPortal
Positive regulation of T cell proliferationManual Assertion Based On ExperimentIDA:ComplexPortal
Positive regulation of T-helper 17 type immune response1 PublicationIC:ComplexPortal
Protein phosphorylationManual Assertion Based On ExperimentTAS:ProtInc
Type I interferon signaling pathwayTAS:Reactome
Type III interferon signaling pathway1 PublicationIC:ComplexPortal
Cellular Location
cytoplasm
cytoskeleton
cytosol
extracellular exosome
interleukin-12 receptor complex
interleukin-23 receptor complex
nucleus
plasma membrane
Involvement in disease
Immunodeficiency 35 (IMD35):
A primary immunodeficiency characterized by recurrent skin abscesses, pneumonia, and highly elevated serum IgE.
PTM
Phosphorylated (PubMed:7638186).
Phosphorylations at Tyr-1054 and Tyr-1055 induce kinase activation (PubMed:8702790).
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For research use only. Not intended for any clinical use.

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