TSPAN8

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This gene is expressed in different carcinomas. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008]

Tetraspanin 8

Biological Process negative regulation of blood coagulation Source:Ensembl
Biological Process regulation of gene expression Source:Ensembl
Biological Process spermatogenesis Source:Ensembl

Membrane

Cytoplasmic: 1-9
Helical: 10-33
Extracellular: 34-57
Helical: 58-72
Cytoplasmic: 73-83
Helical: 84-109
Extracellular: 110-205
Helical: 206-230
Cytoplasmic: 231-237