TRIM29

TRIM29 belongs to the TRIM protein family. It has multiple zinc finger motifs and a leucine zipper motif. It has been proposed to form homo- or heterodimers which are involved in nucleic acid binding. Thus, TRIM29 may act as a transcriptional regulatory factor involved in carcinogenesis and/or differentiation. TRIM29 may also function in the suppression of radiosensitivity since it is associated with ataxia telangiectasia phenotype.

Tripartite Motif Containing 29

Plays a crucial role in the regulation of macrophage activation in response to viral or bacterial infections within the respiratory tract. Mechanistically, TRIM29 interacts with IKBKG/NEMO in the lysosome where it induces its 'Lys-48' ubiquitination and subsequent degradation. In turn, the expression of type I interferons and the production of pro-inflammatory cytokines are inhibited. Additionally, induces the 'Lys-48' ubiquitination of STING1 in a similar way, leading to its degradation.

Biological Process innate immune response Source:UniProtKB-KW
Biological Process negative regulation of protein localization to nucleus Source:Ensembl
Biological Process negative regulation of transcription by RNA polymerase II Source:Ensembl

Cytoplasm
Lysosome
Colocalizes with intermediate filaments.

Constitutively phosphorylated by PKC on serine/threonine in A431 cells.