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Mouse Anti-TRIM29 Recombinant Antibody (CBYJT-4742) (CBMAB-T4280-YJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJT-4742
Antibody Isotype
IgG2a, κ
Application
IF, IHC-P

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
0.01% BSA
Preservative
0.05% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
N-Terminus

Target

Full Name
Tripartite Motif Containing 29
Introduction
TRIM29 belongs to the TRIM protein family. It has multiple zinc finger motifs and a leucine zipper motif. It has been proposed to form homo- or heterodimers which are involved in nucleic acid binding. Thus, TRIM29 may act as a transcriptional regulatory factor involved in carcinogenesis and/or differentiation. TRIM29 may also function in the suppression of radiosensitivity since it is associated with ataxia telangiectasia phenotype.
Entrez Gene ID
23650
UniProt ID
Q14134
Alternative Names
Tripartite Motif Containing 29; Ataxia-Telangiectasia Group D-Associated Protein; Tripartite Motif Protein TRIM29; ATDC; Ataxia Telangiectasia Group D-Associated Protein; Tripartite Motif-Containing Protein 29; Tripartite Motif-Containing 29
Function
Plays a crucial role in the regulation of macrophage activation in response to viral or bacterial infections within the respiratory tract. Mechanistically, TRIM29 interacts with IKBKG/NEMO in the lysosome where it induces its 'Lys-48' ubiquitination and subsequent degradation. In turn, the expression of type I interferons and the production of pro-inflammatory cytokines are inhibited. Additionally, induces the 'Lys-48' ubiquitination of STING1 in a similar way, leading to its degradation.
Biological Process
Biological Process innate immune response Source:UniProtKB-KW
Biological Process negative regulation of protein localization to nucleus Source:Ensembl
Biological Process negative regulation of transcription by RNA polymerase II Source:Ensembl
Cellular Location
Cytoplasm
Lysosome
Colocalizes with intermediate filaments.
PTM
Constitutively phosphorylated by PKC on serine/threonine in A431 cells.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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