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TNFRSF8

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF8/CD30, which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. The engagement of this cytokine expressed on B cell surface plays an inhibitory role in modulating Ig class switch. This cytokine was shown to enhance cell proliferation of some lymphoma cell lines, while to induce cell death and reduce cell proliferation of other lymphoma cell lines. The pleiotropic biologic activities of this cytokine on different CD30+ lymphoma cell lines may play a pathophysiologic role in Hodgkin's and some non-Hodgkin's lymphomas. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Full Name
TNF receptor superfamily member 8
Function
Receptor for TNFSF8/CD30L (PubMed:8391931).
May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF-kappa-B (PubMed:8999898).
Biological Process
Biological Process cellular response to mechanical stimulus Source:UniProtKB1 Publication
Biological Process negative regulation of cell population proliferation Source:ProtInc1 Publication
Biological Process positive regulation of apoptotic process Source:UniProtKB1 Publication
Biological Process positive regulation of TRAIL production Source:UniProtKB1 Publication
Biological Process positive regulation of tumor necrosis factor production Source:UniProtKB1 Publication
Biological Process signal transduction Source:ProtInc1 Publication
Cellular Location
Isoform 1
Cell membrane
Isoform 2
Cytoplasm
Topology
Extracellular: 19-385
Helical: 386-406
Cytoplasmic: 407-595
PTM
Phosphorylated on serine and tyrosine residues (Probable). Isoform 2 is constitutively phosphorylated (PubMed:8839832).

Anti-TNFRSF8 antibodies

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Target: TNFRSF8
Host: Hamster
Antibody Isotype: IgG
Specificity: Mouse
Clone: mCD30.1
Application*: F
Target: TNFRSF8
Host: Hamster
Antibody Isotype: IgG
Specificity: Mouse
Clone: 2SH12-5F
Application*: FN, F
Target: TNFRSF8
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: 82414
Application*: WB, E(Cap)
Target: TNFRSF8
Host: Hamster
Antibody Isotype: IgG, κ
Specificity: Mouse
Clone: CBYY-C0423
Application*: F
Target: TNFRSF8
Host: Hamster
Antibody Isotype: IgG, κ
Specificity: Mouse
Clone: 5K13
Application*: F
Target: TNFRSF8
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: 115705
Application*: WB, EC
Target: TNFRSF8
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBR055F
Application*: WB, IP, IHC, ICC, IHC-IF
Target: TNFRSF8
Host: Mouse
Specificity: Human
Clone: IHC030
Application*: IH
Target: TNFRSF8
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: E1A6Y
Application*: WB, IP
Target: TNFRSF8
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 4C9
Application*: WB, E
Target: TNFRSF8
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: MM0169-5K28
Application*: WB, FN, F
Target: TNFRSF8
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 13H121
Application*: FC
Target: TNFRSF8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 10B1341
Application*: FC, IH
Target: TNFRSF8
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human
Clone: MEM-268
Application*: FC
Target: TNFRSF8
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 7H141
Application*: FC
Target: TNFRSF8
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human
Clone: CBWJC-4543
Application*: IF, IH
Target: TNFRSF8
Host: Hamster
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBWJC-4542
Application*: F
Target: TNFRSF8
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBWJC-4540
Application*: E, P, C, IC
Target: TNFRSF8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-4538
Application*: IH
Target: TNFRSF8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-4537
Application*: IH
Target: TNFRSF8
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBWJC-4535
Application*: F, P
Target: TNFRSF8
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBWJC-4534
Application*: F
Target: TNFRSF8
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBWJC-4533
Application*: WB
Target: TNFRSF8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-4532
Application*: P, WB
Target: TNFRSF8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-2448
Application*: F
Target: TNFRSF8
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBWJC-2447
Application*: F, P, IF
Target: TNFRSF8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: Ber-H8
Application*: C, P, F
Target: TNFRSF8
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: AC10
Application*: F
Target: TNFRSF8
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBXC-1766
Application*: WB, IP, IF, E
Target: TNFRSF8
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBXC-1745
Application*: WB, IP, IF, E
Target: TNFRSF8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-2161
Application*: P, WB
Target: TNFRSF8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-1323
Application*: WB
Target: TNFRSF8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-2156
Application*: E, F, WB
Target: TNFRSF8
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human
Clone: KI 1
Application*: IF, C
Target: TNFRSF8
Host: Hamster
Antibody Isotype: IgG, κ
Specificity: Mouse
Clone: CBXC-1618
Application*: F
Target: TNFRSF8
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CON6D/ C2
Application*: P
Target: TNFRSF8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: Ber-H2
Application*: F
Target: TNFRSF8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: Ki-2
Application*: F
Target: TNFRSF8
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXC-1324
Application*: F
Target: TNFRSF8
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: SPM609
Application*: F, P, IF
Target: TNFRSF8
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: SPM121
Application*: F, P, IF
Target: TNFRSF8
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: rKi-1/779
Application*: F, IF, P
Target: TNFRSF8
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: Ki-4
Application*: F, E, IH, IF, MC
Target: TNFRSF8
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: Ki-3
Application*: F, E, IH, IF, MC
Target: TNFRSF8
Host: Rabbit
Antibody Isotype: IgG, κ
Specificity: Human
Clone: Ki-1/1747R
Application*: F, IF, P, MC
Target: TNFRSF8
Host: Rabbit
Antibody Isotype: IgG, κ
Specificity: Human
Clone: Ki-1/1505R
Application*: F, IF, P
Target: TNFRSF8
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: Ki-1/1505
Application*: F, P, IF
Target: TNFRSF8
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CD30/412
Application*: F, E, IF, P, C
Target: TNFRSF8
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYY-C2006
Application*: F
Target: TNFRSF8
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: CBYY-C2005
Application*: F, WB, A
Target: TNFRSF8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C2004
Application*: WB
Target: TNFRSF8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C2003
Application*: IH
Target: TNFRSF8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C2002
Application*: WB
Target: TNFRSF8
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYY-C2001
Application*: E
Target: TNFRSF8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C2000
Application*: P, WB
Target: TNFRSF8
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 81337
Application*: WB, F, MC, MC
Target: TNFRSF8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C0669
Application*: WB
Target: TNFRSF8
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBYY-C0611
Application*: F
Target: TNFRSF8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C0302
Application*: F
Target: Tnfrsf8
Host: Hamster
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBYJT-3880
Application*: F, FN
Target: TNFRSF8
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYJT-3877
Application*: P, IF, IC, F
Target: TNFRSF8
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYJT-3876
Application*: P, IF, IC, F
Target: TNFRSF8
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYJT-3875
Application*: P, IF, IC, F
Target: TNFRSF8
Host: Rabbit
Antibody Isotype: IgG, κ
Specificity: Human
Clone: CBYJT-3874
Application*: P, IF, IC, F
Target: TNFRSF8
Host: Rabbit
Antibody Isotype: IgG, κ
Specificity: Human
Clone: CBYJT-3873
Application*: P, IF, IC, F
Target: TNFRSF8
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYJT-3872
Application*: P, IF, IC, F
Target: TNFRSF8
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYJT-3871
Application*: IH
Target: TNFRSF8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3870
Application*: WB, IH, F
Target: TNFRSF8
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: CBYJT-3869
Application*: WB, F, S
Target: TNFRSF8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3868
Application*: WB, IH, F
Target: TNFRSF8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3867
Application*: WB, IH, F
Target: TNFRSF8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3866
Application*: WB, IH, F
Target: TNFRSF8
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYJT-3865
Application*: WB, IH, F
Target: TNFRSF8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-3864
Application*: WB, IH, F
Target: TNFRSF8
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: CBYJT-3863
Application*: F, WB
Target: TNFRSF8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-3183
Application*: E, WB
Target: TNFRSF8
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYC-3182
Application*: E
Target: TNFRSF8
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBFYC-3181
Application*: WB, EC
Target: TNFRSF8
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYC-3180
Application*: WB
Target: TNFRSF8
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYC-3179
Application*: P, WB
Target: TNFRSF8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-3178
Application*: P, WB
Target: TNFRSF8
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYC-3177
Application*: WB
Target: TNFRSF8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-3176
Application*: F
Target: TNFRSF8
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYC-0215
Application*: F
Target: TNFRSF8
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYC-0038
Application*: F
Target: TNFRSF8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-0037
Application*: F
Target: TNFRSF8
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 002
Application*: F
Target: TNFRSF8
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: Ki-1/779
Application*: F, IF, P
Target: TNFRSF8
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CDLA30-1
Application*: F, P
Target: TNFRSF8
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 8J238
Application*: F
Target: TNFRSF8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 81316
Application*: WB
Target: TNFRSF8
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: 5K28
Application*: C, WB, A
Target: TNFRSF8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 4B3
Application*: WB
Target: TNFRSF8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3H1201
Application*: IH
Target: TNFRSF8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3F8
Application*: WB
Target: TNFRSF8
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 3B9
Application*: E
Target: TNFRSF8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3B10
Application*: F, E, WB
Target: TNFRSF8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3A2
Application*: P, WB
Target: TNFRSF8
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2G7
Application*: F, P
Target: TNFRSF8
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 2G2
Application*: WB
More Infomation
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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