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Mouse Anti-TNFRSF8 Recombinant Antibody (CBYY-C2003) (CBMAB-C3441-YY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYY-C2003
Antibody Isotype
IgG1
Application
IHC

Basic Information

Immunogen
Recombinant human CD30 antigen
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Tissue culture supernatant
Preservative
50% glycerol
Concentration
Lyophilized
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
TNF receptor superfamily member 8
Entrez Gene ID
943
UniProt ID
P28908
Alternative Names
TRNA Splicing Endonuclease Subunit 15; TSEN15 TRNA Splicing Endonuclease Subunit; TRNA-Intron Endonuclease Sen15; C1orf19; Sen15; TRNA Splicing Endonuclease 15 Homolog (S. Cerevisiae); TRNA-Splicing Endonuclease Subunit Sen15;
Function
Receptor for TNFSF8/CD30L (PubMed:8391931).
May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF-kappa-B (PubMed:8999898).
Biological Process
Biological Process cellular response to mechanical stimulus Source:UniProtKB1 Publication
Biological Process negative regulation of cell population proliferation Source:ProtInc1 Publication
Biological Process positive regulation of apoptotic process Source:UniProtKB1 Publication
Biological Process positive regulation of TRAIL production Source:UniProtKB1 Publication
Biological Process positive regulation of tumor necrosis factor production Source:UniProtKB1 Publication
Biological Process signal transduction Source:ProtInc1 Publication
Cellular Location
Isoform 1
Cell membrane
Isoform 2
Cytoplasm
Topology
Extracellular: 19-385
Helical: 386-406
Cytoplasmic: 407-595
PTM
Phosphorylated on serine and tyrosine residues (Probable). Isoform 2 is constitutively phosphorylated (PubMed:8839832).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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